November 12, 2014
Tomography, X-Ray Computed
Notes: Hwang, Eui Tae
Cho, Jae Hee
Korean J Gastroenterol. 2013 Dec;62(6):379-81.
Reference Type: Journal Article
Record Number: 4683Author: Ikeura, T., Manfredi, R., Zamboni, G., Negrelli, R., Capelli, P., Amodio, A., Calio, A., Colletta, G., Gabbrielli, A., Benini, L., Okazaki, K., Vantini, I. and Frulloni, L.
Title: Application of international consensus diagnostic criteria to an Italian series of autoimmune pancreatitis
Journal: United European Gastroenterol J
Short Title: Application of international consensus diagnostic criteria to an Italian series of autoimmune pancreatitis
Alternate Journal: United European gastroenterology journal
ISSN: 2050-6406 (Print)
Accession Number: 24917972
Abstract: BACKGROUND: International consensus diagnostic criteria (ICDC) have been proposed to classify autoimmune pancreatitis (AIP) in type 1, type 2, or not otherwise specified. OBJECTIVE: Aim was to apply the ICDC to an Italian series of patients to evaluate the incidence and clinical profiles among different subtypes of AIP. METHODS: we re-evaluated and classified 92 patients diagnosed by Verona criteria, according to the ICDC. RESULTS: Out of 92 patients, 59 (64%) were diagnosed as type 1, 17 (18%) as type 2, and 15 (16%) as not otherwise specified according to the ICDC. A significant difference between type 1 and type 2 were found for age (54.5 +/- 14.5 vs. 34.4 +/- 13.9 respectively; p < 0.0001), male sex (76 vs. 47%; p = 0.007), jaundice (66 vs. 18%; p = 0.002) and acute pancreatitis (9 vs. 47%; p < 0.0001), elevated serum IgG4 levels (85 vs. 7%; p < 0.0001), inflammatory bowel disease (8 vs. 82%; < 0.0001), and relapse of the disease (34 vs. 6%; p = 0.058). Imaging and response to steroids in the not-otherwise-specified group were similar to type 1 and 2. CONCLUSIONS: Type 1 has a different clinical profile from type 2 autoimmune pancreatitis. The not-otherwise-specified group has peculiar clinical features which are shared both with type 1 or type 2 groups.