November 12, 2014
Notes: Hanna, Mina S
Portal, Andrew J
Dhanda, Ashwin D
Frontline Gastroenterol. 2014 Apr;5(2):103-110. Epub 2013 Sep 3.
Author Address: Department of Gastroenterology and Hepatology , Bristol Royal Infirmary, University Hospitals Bristol NHS Trust , Bristol , UK.
School of Clinical Sciences, University of Bristol , Bristol , UK.
Department of Gastroenterology , Frenchay Hospital, North Bristol NHS Trust , Bristol , UK.
Reference Type: Journal Article
Record Number: 4675Author: Hansen, T. M., Nilsson, M., Gram, M. and Frokjaer, J. B.
Title: Morphological and functional evaluation of chronic pancreatitis with magnetic resonance imaging
Journal: World J Gastroenterol
Date: Nov 14
Short Title: Morphological and functional evaluation of chronic pancreatitis with magnetic resonance imaging
Alternate Journal: World journal of gastroenterology : WJG
ISSN: 2219-2840 (Electronic)
Accession Number: 24259954
Cholangiopancreatography, Magnetic Resonance
Contrast Media/diagnostic use
*Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
*Pancreatic Function Tests
Predictive Value of Tests
Severity of Illness Index
Abstract: Magnetic resonance imaging (MRI) techniques for assessment of morphology and function of the pancreas have been improved dramatically the recent years and MRI is very often used in diagnosing and follow-up of chronic pancreatitis (CP) patients. Standard MRI including fat-suppressed T1-weighted and T2-weighted imaging techniques reveal decreased signal and glandular atrophy of the pancreas in CP. In contrast-enhanced MRI of the pancreas in CP the pancreatic signal is usually reduced and delayed due to decreased perfusion as a result of chronic inflammation and fibrosis. Thus, morphological changes of the ductal system can be assessed by magnetic resonance cholangiopancreatography (MRCP). Furthermore, secretin-stimulated MRCP is a valuable technique to evaluate side branch pathology and the exocrine function of the pancreas and diffusion weighted imaging can be used to quantify both parenchymal fibrotic changes and the exocrine function of the pancreas. These standard and advanced MRI techniques are supplementary techniques to reveal morphological and functional changes of the pancreas in CP. Recently, spectroscopy has been used for assessment of metabolite concentrations in-vivo in different tissues and may have the potential to offer better tissue characterization of the pancreas. Hence, the purpose of the present review is to provide an update on standard and advanced MRI techniques of the pancreas in CP.