November 12, 2014
Notes: Garcia-Hernandez, Violeta
Calvo, Jose J
Research Support, Non-U.S. Gov’t
Biochim Biophys Acta. 2014 Feb;1842(2):192-201. doi: 10.1016/j.bbadis.2013.11.003. Epub 2013 Nov 10.
Author Address: Department of Biochemistry and Molecular Biology, University of Salamanca, Spain.
Department of Physiology and Pharmacology, University of Salamanca, Spain.
Department of Biochemistry and Molecular Biology, University of Salamanca, Spain. Electronic address: firstname.lastname@example.org.
Reference Type: Journal Article
Record Number: 4667Author: Garip, G., Sarandol, E. and Kaya, E.
Title: Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis
Journal: World J Gastroenterol
Date: Nov 28
Short Title: Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis
Alternate Journal: World journal of gastroenterology : WJG
ISSN: 2219-2840 (Electronic)
Accession Number: 24307801
Aged, 80 and over
Clinical Enzyme Tests
Exocrine Pancreatic Insufficiency/complications/diagnosis
Glucose Tolerance Test
Pancreatic Function Tests
Pancreatitis, Acute Necrotizing/*diagnosis/metabolism/pathology/surgery
Predictive Value of Tests
Severity of Illness Index
Tomography, X-Ray Computed
Abstract: AIM: To evaluate the effects of disease severity and necrosis on organ dysfunctions in acute pancreatitis (AP). METHODS: One hundred and nine patients treated as AP between March 2003 and September 2007 with at least 6 mo follow-up were included. Patients were classified according to severity of the disease, necrosis ratio and localization. Subjective clinical evaluation and fecal pancreatic elastase-I (FPE-I) were used for exocrine dysfunction evaluation, and oral glucose tolerance test was completed for endocrine dysfunction. The correlation of disease severity, necrosis ratio and localization with exocrine and endocrine dysfunction were investigated. RESULTS: There were 58 male and 51 female patients, and mean age was 56.5 +/- 15.7. Of the patients, 35.8% had severe AP (SAP) and 27.5% had pancreatic necrosis. Exocrine dysfunction was identified in 13.7% of the patients [17.9% were in SAP, 11.4% were in mild AP (MAP)] and 34.7% of all of the patients had endocrine dysfunction (56.4% in SAP and 23.2% in MAP). In patients with SAP and necrotizing AP (NAP), FPE-Ilevels were lower than the others (P < 0.05 and 0.001 respectively) and in patients having pancreatic head necrosis or near total necrosis, FPE-1 levels were lower than 200 mug/g stool. Forty percent of the patients who had undergone necrosectomy developed exocrine dysfunction. Endocrine dysfunction was more significant in patients with SAP and NAP (P < 0.001). All of the patients in the necrosectomy group had endocrine dysfunction. CONCLUSION: Patients with SAP, NAP, pancreatic head necrosis and necrosectomy should be followed for pancreatic functions.