November 12, 2014
Notes: Zhang, Dong-lin
J Huazhong Univ Sci Technolog Med Sci. 2013 Jun;33(3):361-7. doi: 10.1007/s11596-013-1125-8. Epub 2013 Jun 17.
Author Address: Department of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China. email@example.com
Reference Type: Journal Article
Record Number: 5157Author: Zhang, L., Chen, Y., Wang, L., Chen, X. P., Zhang, W. G., Wang, C. Y. and Wu, H. S.
Title: Chloroquine relieves acute lung injury in rats with acute hemorrhagic necrotizing pancreatitis
Journal: J Huazhong Univ Sci Technolog Med Sci
Short Title: Chloroquine relieves acute lung injury in rats with acute hemorrhagic necrotizing pancreatitis
Alternate Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
ISSN: 1672-0733 (Print)
Accession Number: 23771660
Keywords: Acute Lung Injury/*drug therapy/*immunology/pathology
Pancreatitis, Acute Necrotizing/*complications/pathology
Toll-Like Receptor 4/*immunology
Abstract: This study preliminarily investigated the mechanism by which chloroquine (CQ) relieves acute lung injury (ALI) complicated in acute hemorrhagic necrotizing pancreatitis (AHNP). Sixty male Wistar rats were randomized into sham-operated group (group A, n=10), AHNP group (group B, n=10), L-arginine-treated group (group C, n=10), L-N-nitro-L-arginine methyl ester (NAME)-treated group (group D, n=10), CQ-treated group (group E, n=10) and CQ+L-NAME-treated group (group F, n=10). TLR4 expression was measured by using real time-PCR and Western blotting respectively. The results showed that, in the