November 12, 2014
Notes: Ye, Xiao-Hua
World J Gastroenterol. 2013 Apr 28;19(16):2492-500. doi: 10.3748/wjg.v19.i16.2492.
Author Address: Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China.
Reference Type: Journal Article
Record Number: 5258Author: Yoshioka, W., Mori, T., Nagahama, K. and Tamura, T.
Title: Biopsy-proven drug-induced tubulointerstitial nephritis in a patient with acute kidney injury and alcoholic severe acute pancreatitis
Journal: BMJ Case Rep
Short Title: Biopsy-proven drug-induced tubulointerstitial nephritis in a patient with acute kidney injury and alcoholic severe acute pancreatitis
Alternate Journal: BMJ case reports
ISSN: 1757-790X (Electronic)
Accession Number: 23645698
Keywords: Acute Kidney Injury/*complications/drug therapy/pathology
Adrenal Cortex Hormones/therapeutic use
Nephritis, Interstitial/chemically induced/*complications/drug therapy/pathology
Abstract: We report a 49-year-old man with alcoholic severe acute pancreatitis (SAP) complicated by drug-induced acute tubulointerstitial nephritis (DI-AIN). Oliguria persisted and became anuric again on day 17 despite improvement of pancreatitis. He presented rash, fever and eosinophilia from day 20. Renal biopsy was performed for dialysis-dependent acute kidney injury (AKI), DI-AIN was revealed, and prompt use of corticosteroids fully restored his renal function. This diagnosis might be missed because it is difficult to perform renal biopsy in such a clinical situation. If the patient’s general condition allows, renal biopsy should be performed and reversible AKI must be distinguished from many cases of irreversible AKI complicated by SAP. This is the first report of biopsy-proven DI-AIN associated with SAP, suggesting the importance of biopsy for distinguishing DI-AIN in persisting AKI of SAP.