November 12, 2014
Notes: Yaman, Ayhan
Pediatr Emerg Care. 2013 May;29(5):659-61. doi: 10.1097/PEC.0b013e31828ec2d5.
Author Address: Pediatric Intensive Care Unit, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey. firstname.lastname@example.org
Reference Type: Journal Article
Record Number: 5132Author: Yanar, F., Agcaoglu, O., Sarici, I. S., Ozcinar, B., Gok, A. F., Gunay, K. and Ertekin, C.
Title: Clinical challenges in drug induced pancreatitis: Presentation of two cases and review of the literature
Journal: Int J Surg Case Rep
Short Title: Clinical challenges in drug induced pancreatitis: Presentation of two cases and review of the literature
Alternate Journal: International journal of surgery case reports
ISSN: 2210-2612 (Electronic)
Accession Number: 23810919
Abstract: INTRODUCTION: A wide variety of drugs have been reported to cause pancreatitis. Although the incidence of drug induced acute pancreatitis is low, the disease is associated with substantial morbidity and mortality, which makes timely identification of the causative agent important. PRESENTATION OF CASE: Herein, we report two patients with clinical, biochemical, and radiological evidence of acute pancreatitis. There were no etiologic factors except their prescribed drugs. DISCUSSION: The majority of patients with acute pancreatitis recover uneventfully, but there remains an uncontrollable risk of mortality. It is prudent to withdraw a medication with a known association with acute pancreatitis. Necessity of multi-drug regimens especially in oncological patients however, presents a challenge. CONCLUSION: Corticosteroid pulse therapy was easily detectable as the causative agent in our first case, but combined anti-neoplastic drug therapy and additional multi-drug regimen presented great difficulties in identifying single causative agent in our second patient.