November 12, 2014
Notes: Wang, Zi-kai
Randomized Controlled Trial
Chin Med J (Engl). 2013 Jul;126(13):2403-8.
Author Address: Department of Gastroenterology and Hepatology, Chinese People’s Liberation Army General Hospital, Beijing 100853, China.
Reference Type: Journal Article
Record Number: 5327Author: Watanabe, T., Maruyama, M., Ito, T., Kanai, K., Oguchi, T., Muraki, T., Hamano, H., Arakura, N., Ota, M. and Kawa, S.
Title: Two siblings with type 1 autoimmune pancreatitis
Journal: Intern Med
Short Title: Two siblings with type 1 autoimmune pancreatitis
Alternate Journal: Internal medicine
ISSN: 1349-7235 (Electronic)
Accession Number: 23583993
Keywords: Autoimmune Diseases/*classification/*genetics/immunology
Abstract: Type 1 autoimmune pancreatitis (AIP) is characterized by a high serum IgG4 concentration and is closely associated with the HLA-DRB1(*)04:05-DQB1(*)04:01 haplotype, for which family studies may disclose its immunogenetic significance. In the present study, we encountered two male siblings with type 1 AIP who exhibited diffuse pancreatic swelling with a capsule-like rim and diffuse pancreatic duct stricture. The younger brother also displayed characteristic IgG4-related sialadenitis and retroperitoneal fibrosis. Contrary to our expectations, the siblings showed only normal or slightly elevated values of serum IgG4 and no HLA DRB1(*)04:05-DQB1(*)04:01 haplotype, suggesting that type 1 autoimmune pancreatitis is associated with multiple immunogenetic factors.
Notes: Watanabe, Takayuki