November 12, 2014
Notes: Fitzgibbons, Timothy P
Meyer, Theo E
Am J Cardiol. 2014 Jan 1;113(1):123-6. doi: 10.1016/j.amjcard.2013.09.026. Epub 2013 Oct 3.
Author Address: Heart Failure Program, Division of Cardiovascular Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts.
Dynabio S.A., Marseille, France.
Heart Failure Program, Division of Cardiovascular Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts. Electronic address: firstname.lastname@example.org.
Reference Type: Journal Article
Record Number: 4662Author: Francis, T., Graf, A., Hodges, K., Kennedy, L., Hargrove, L., Price, M., Kearney, K. and Francis, H.
Title: Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Journal: Hepatobiliary Surg Nutr
Short Title: Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Alternate Journal: Hepatobiliary surgery and nutrition
ISSN: 2304-3881 (Print)
Accession Number: 24570946
Abstract: The pancreas is a dynamic organ that performs a multitude of functions within the body. Diseases that target the pancreas, like pancreatitis and pancreatic cancer, are devastating and often fatal to the suffering patient. Histamine and histamine receptors (H1-H4HRs) have been found to play a critical role in biliary diseases. Accordingly, the biliary tract and the pancreas share similarities with regards to morphological, phenotypical and functional features and disease progression, studies related the role of H1-H4HRs in pancreatic diseases are important. In this review, we have highlighted the role that histamine, histidine decarboxylase (HDC), histamine receptors and mast cells (the main source of histamine in the body) play during both pancreatitis and pancreatic cancer. The objective of the review is to demonstrate that histamine and histamine signaling may be a potential therapeutic avenue towards treatment strategies for pancreatic diseases.