November 12, 2014
Notes: Reddy, Sagili Vijaya Bhaskar
Randomized Controlled Trial
Research Support, Non-U.S. Gov’t
Calcif Tissue Int. 2013 Jul;93(1):48-54. doi: 10.1007/s00223-013-9726-6. Epub 2013 Apr 6.
Author Address: Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.
Reference Type: Journal Article
Record Number: 5180Author: Rho, E. S., Kim, E., Koh, H., Yoo, H. W., Lee, B. H. and Kim, G. H.
Title: Two cases of chronic pancreatitis associated with anomalous pancreaticobiliary ductal union and SPINK1 mutation
Journal: Korean J Pediatr
Short Title: Two cases of chronic pancreatitis associated with anomalous pancreaticobiliary ductal union and SPINK1 mutation
Alternate Journal: Korean journal of pediatrics
ISSN: 1738-1061 (Print)
Accession Number: 23741238
Abstract: Chronic pancreatitis is a progressive inflammatory disease resulting from repeated episodes of acute pancreatitis that impair exocrine function and eventually produce endocrine insufficiency. Some causes of chronic pancreatitis appear to be associated with alterations in the serine-protease inhibitor, Kazal type 1 (SPINK1), cationic trypsinogen (PRSS1), and cystic fibrosis-transmembrane conductance regulator (CFTR) genes, or with structural disorders in the pancreaticobiliary ductal system, such as pancreatic divisum or anomalous pancreaticobiliary ductal union (APBDU). However, it is unusual to observe both genetic alteration and structural anomaly. Here, we report 2 cases with both APBDU and a mutation in the SPINK1 genes, and we discuss the implications of these findings in clinical practice.
Notes: Rho, Eun Sam