November 12, 2014
Notes: Negm, Ahmed A
Manns, Michael P
Lankisch, Tim O
Gastrointest Endosc. 2013 Aug;78(2):303-11. doi: 10.1016/j.gie.2013.03.001. Epub 2013 Apr 30.
Author Address: Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany.
Reference Type: Journal Article
Record Number: 5216Author: Nichitailo, M. E., Kravchenko, D. A., Shpon’ka, I. S., Medvetskii, E. B., Savitskaia, I. M., Bulik, II and Khil’ko Iu, A.
Title: [Inhibition of the stellate cells using lisinopril and lovastatin for prophylaxis of pancreatic stump fibrosis after performance of distal resection in a model of chronic alcoholic pancreatitis]
Journal: Klin Khir
Short Title: [Inhibition of the stellate cells using lisinopril and lovastatin for prophylaxis of pancreatic stump fibrosis after performance of distal resection in a model of chronic alcoholic pancreatitis]
Alternate Journal: Klinichna khirurhiia / Ministerstvo okhorony zdorov’ia Ukrainy, Naukove tovarystvo khirurhiv Ukrainy
ISSN: 0023-2130 (Print)
Accession Number: 23705487
Angiotensin-Converting Enzyme Inhibitors/*pharmacology
Fibrosis/prevention & control
Gene Expression/drug effects
Glial Fibrillary Acidic Protein/genetics/metabolism
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
Matrix Metalloproteinase 1
Pancreatic Stellate Cells/drug effects/metabolism/pathology
Pancreatitis, Alcoholic/*drug therapy/genetics/metabolism/pathology
Tissue Inhibitor of Metalloproteinase-2/genetics/metabolism
Abstract: Complex application of lisinopril (inhibitor of angiotensin-converting enzyme) and lovastatin (inhibitor of HMG-CoA reductase) inhibits pancreatic fibrosis in the rats, having alcoholic chronic pancreatitis after distal pancreatic resection (DPR). Lisinopril and lovastatin were injected to the rats after DPR in dose 10 mg/kg during 3 weeks. Immunohistochemical markets, such as alpha-smooth-muscle actin (alpha-SMA), desmin, glial fibrillary acidic protein (GFAP), vimentin, and expression of matrix metalloproteinase-1 (MMP-1) as well as inhibitor of matrix metalloproteinase-2 (TIMP-2) were detected for estimation of therapeutic impact on activity and quantity of stellate pancreatic cells. Under the influence of lisinopril and lovastatin there were observed lowering in the stellate pancreatic cells activity and in expression of SMA, desmin, GFAP, vimentin and TIMP-2, the MMP-1 and TIMP-2 ratio have had increased significantly and severity of fibrotic pancreatic affection had reduced trustworthy in comparison w such, occurring in a control group.