November 12, 2014
Notes: Liu, Wen-Cheng
J Microbiol Immunol Infect. 2013 Oct;46(5):393-6. doi: 10.1016/j.jmii.2013.04.007. Epub 2013 Jun 10.
Author Address: Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, ROC.
Reference Type: Journal Article
Record Number: 5141Author: Lohr, J. M., Haas, S. L., Lindgren, F., Enochsson, L., Hedstrom, A., Swahn, F., Segersvard, R. and Arnelo, U.
Title: Conservative treatment of chronic pancreatitis
Journal: Dig Dis
Short Title: Conservative treatment of chronic pancreatitis
Alternate Journal: Digestive diseases
ISSN: 1421-9875 (Electronic)
Accession Number: 23797122
Enzyme Replacement Therapy
Exocrine Pancreatic Insufficiency/therapy
Abstract: BACKGROUND: Chronic pancreatitis is a progressive inflammatory disease giving rise to several complications that need to be treated accordingly. Because pancreatic surgery has significant morbidity and mortality, less invasive therapy seems to be an attractive option. AIM: This paper reviews current state-of-the-art strategies to treat chronic pancreatitis without surgery and the current guidelines for the medical therapy of chronic pancreatitis. RESULTS: Endoscopic therapy of complications of chronic pancreatitis such as pain, main pancreatic duct strictures and stones as well as pseudocysts is technically feasible and safe. The long-term outcome, however, is inferior to definitive surgical procedures such as resection or drainage. On the other hand, the medical therapy of pancreatic endocrine and exocrine insufficiency is well established and evidence based. CONCLUSIONS: Endoscopic therapy may be an option to bridge for surgery and in children/young adolescents and those unfit for surgery. Pain in chronic pancreatitis as well as treatment of pancreatic exocrine insufficiency follows established guidelines.