November 12, 2014
Title: Models of acute and chronic pancreatitis
Short Title: Models of acute and chronic pancreatitis
Alternate Journal: Gastroenterology
ISSN: 1528-0012 (Electronic)
Accession Number: 23622127
Keywords: Acute Disease
Disease Models, Animal
Severity of Illness Index
Abstract: Animal models of acute and chronic pancreatitis have been created to examine mechanisms of pathogenesis, test therapeutic interventions, and study the influence of inflammation on the development of pancreatic cancer. In vitro models can be used to study early stage, short-term processes that involve acinar cell responses. Rodent models reproducibly develop mild or severe disease. One of the most commonly used pancreatitis models is created by administration of supraphysiologic concentrations of caerulein, an ortholog of cholecystokinin. Induction of chronic pancreatitis with factors thought to have a role in human disease, such as combinations of lipopolysaccharide and chronic ethanol feeding, might be relevant to human disease. Models of autoimmune chronic pancreatitis have also been developed. Most models, particularly of chronic pancreatitis, require further characterization to determine which features of human disease they include.
Notes: Lerch, Markus M
Gorelick, Fred S
R01 DK54021/DK/NIDDK NIH HHS/
R21 AA020847/AA/NIAAA NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov’t
Research Support, U.S. Gov’t, Non-P.H.S.
Gastroenterology. 2013 Jun;144(6):1180-93. doi: 10.1053/j.gastro.2012.12.043.
Author Address: Department of Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch-Strasse, Greifswald, Germany. firstname.lastname@example.org