November 12, 2014
Notes: Francisco, Maria
Rev Esp Enferm Dig. 2013 Feb;105(2):84-92.
Reference Type: Journal Article
Record Number: 5234Author: Fukushima, H., Fukushima, T., Suzuki, R., Enokizono, T., Matsunaga, M., Nakao, T., Koike, K., Mori, K., Matsueda, K. and Sumazaki, R.
Title: Continuous regional arterial infusion effective for children with acute necrotizing pancreatitis even under neutropenia
Journal: Pediatr Int
Short Title: Continuous regional arterial infusion effective for children with acute necrotizing pancreatitis even under neutropenia
Alternate Journal: Pediatrics international : official journal of the Japan Pediatric Society
ISSN: 1442-200X (Electronic)
Accession Number: 23679174
Anti-Bacterial Agents/*administration & dosage
Pancreatitis, Acute Necrotizing/complications/*drug therapy
Protease Inhibitors/*administration & dosage
Abstract: Severe acute pancreatitis is one of the critical conditions that may develop in children with cancer. The leading cause of death due to acute pancreatitis is infectious pancreatitis or circulation collapse. Therefore, patients who develop acute pancreatitis while undergoing chemotherapy or after hematopoietic transplantation are at risk for a life-threatening and fatal course. We treated 140 patients with malignancy from April 2002 to March 2009 at our hospital and encountered 3 patients under neutropenia who developed severe acute pancreatitis. Two of them were successfully treated with continuous regional arterial infusion of a protease inhibitor and antibiotic even under agranulocytosis. Another patient was treated with conventional therapy with intravenous antibiotics plus a protease inhibitor and total or partial parenteral nutrition. Even though the two patients treated with continuous regional arterial infusion presented much more severe conditions, their symptoms resolved earlier. In conclusion, acute pancreatitis is one of the severe complications of childhood malignancy. Even under agranulocytosis, continuous regional arterial infusion of a protease inhibitor and antibiotic was well tolerated and effective among our cases and might reduce early death due to pancreatitis.