November 12, 2014
Notes: Dragovic, Gordana
Research Support, Non-U.S. Gov’t
Asian Pac J Trop Biomed. 2013 Jun;3(6):422-5. doi: 10.1016/S2221-1691(13)60091-X.
Author Address: Institute of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia.
Reference Type: Journal Article
Record Number: 5213Author: Du, B. Q., Yang, Y. M., Chen, Y. H., Liu, X. B. and Mai, G.
Title: N-acetylcysteine improves pancreatic microcirculation and alleviates the severity of acute necrotizing pancreatitis
Journal: Gut Liver
Short Title: N-acetylcysteine improves pancreatic microcirculation and alleviates the severity of acute necrotizing pancreatitis
Alternate Journal: Gut and liver
ISSN: 1976-2283 (Print)
Accession Number: 23710319
Abstract: BACKGROUND/AIMS: To investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP). METHODS: Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group. The ANP model was established by a retrograde injection of 3% sodium taurocholate into the pancreatic duct. The NAC-treated group received an intravenous infusion of NAC just 2 hours before and 30 minutes after the induction of ANP. The pancreatic microvascular perfusion was measured with laser Doppler flowmetry and pancreatic samples were collected for histological examination. RESULTS: The microvascular perfusion in the NAC-treated group decreased slightly and exhibited a significant increase compared to the ANP group (p<0.01). A pathological examination revealed that edema and inflammatory infiltration decreased, and the hemorrhaging and necrosis of the pancreas were significantly reduced. CONCLUSIONS: NAC could improve pancreatic microvascular perfusion and alleviate the severity of sodium taurocholate-induced ANP, possibly representing a new therapeutic approach to prevent the progression of ANP.