November 12, 2014
Notes: Chen, Er-Zhen
Research Support, Non-U.S. Gov’t
Hepatobiliary Pancreat Dis Int. 2013 Jun;12(3):317-23.
Author Address: Emergency Intensive Care Unit, and Surgical Intensive Care Unit, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.
Reference Type: Journal Article
Record Number: 5176Author: Chen, Y., Zhang, Z. W., Wang, B., Yin, W. H., Zuo, Y. Y., Kang, Y. and Liu, J.
Title: [Relationship between early serum albumin variation and prognosis in patients with severe acute pancreatitis treated in ICU]
Journal: Sichuan Da Xue Xue Bao Yi Xue Ban
Short Title: [Relationship between early serum albumin variation and prognosis in patients with severe acute pancreatitis treated in ICU]
Alternate Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
ISSN: 1672-173X (Print)
Accession Number: 23745263
Abstract: OBJECTIVE: To investigate the relationship between serum albumin variation within 24 hours of ICU admission and prognosis in critically ill patients with sever acute pancreatitis(SAP). METHODS: We retrospectively analyzed all the clinical data of the patients with SAP treated in ICU from Jul. 2005 to Jun. 2010. The patients were divided into two groups, survival group (n = 131) and death group (n = 108). Clinical and laboratory data, outcomes, and serum albumin within 24 hours after admission to ICU of those patients were evaluated respectively, and Logistic regression analysis was performed. RESULTS: Significant differences were existed between two groups (P < 0.01) in average age, the score of acute physiology and chronic health evaluation II (APACHE II), Ranson criteria, the score of sequential organ failure assessment (SOFA), and albumin variation within 24 hours(Serum albumin descent degree and ratio in early stage). However, sex ratio, mean serum albumin concentration within 24 hours, and onset time did not have significant differences (P > 0.05). The area under ROC curve for albumin variation within 24 hours were 0. 728 and 0. 742, the best cut-off values were 4.25 g/L (sensitivity 61.45%, specificity 81.67%) and 13.5% (sensitivity 62.65%, specificity 78.33%), respectively. Multiple logistic regression analysis showed that albumin variation within 24 hours was associated with death. CONCLUSION: The albumin variation within 24 hours was the risk factors for poor prognosis of critically ill SAP in early stage.