November 12, 2014
Thiobarbituric Acid Reactive Substances/metabolism
Tumor Necrosis Factor-alpha/metabolism
Abstract: The efficacy of lawsone against L-arginine induced acute pancreatitis was determined at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-alpha, C-reactive proteins and interleukin (IL)], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation (thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Lawsone and methylprednisolone treatments significantly attenuated the L-arginine- induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-alpha and IL-6 and significantly lowered pancreatic levels of MPO, TBARS, and nitrate/nitrite. The histoimmunological findings further proved the amelioration of pancreatic injury by lawsone and further proved anti-inflammatory and antioxidant agent property of lawsone.
Notes: Biradar, Sandeep
Indian J Exp Biol. 2013 Mar;51(3):256-61.
Author Address: Department of Pharmacology, G. Pulla Reddy College of Pharmacy, Hyderabad, India. firstname.lastname@example.org
Reference Type: Journal Article
Record Number: 5250Author: Bishop, M., Xenoulis, P. and Steiner, J. M.
Title: Association between this SPINK1 variant and clinically detectable pancreatitis
Journal: J Vet Intern Med
Short Title: Association between this SPINK1 variant and clinically detectable pancreatitis
Alternate Journal: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine
ISSN: 1939-1676 (Electronic)
Accession Number: 23659717
Gene Expression Regulation/*physiology
Serine Proteinase Inhibitors/*metabolism
Notes: Bishop, Micah