November 12, 2014
Notes: Zhang, Ting-Ting
Research Support, Non-U.S. Gov’t
Pancreatology. 2013 Sep-Oct;13(5):491-7. doi: 10.1016/j.pan.2013.08.003. Epub 2013 Aug 22.
Author Address: Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong Medical University, Shanghai 200092, China.
Reference Type: Journal Article
Record Number: 4962Author: Zhang, X., Sun, S., Li, S., Feng, X., Wang, S., Liu, C., Hang, Z., Tong, C., Zhu, C., Bai, B., Xu, B., Feng, Q. and Zhao, Q.
Title: Early classic hemofiltration exhibits no benefits in severe acute pancreatitis with early organ failure: a retrospective case-matched study
Journal: Artif Organs
Short Title: Early classic hemofiltration exhibits no benefits in severe acute pancreatitis with early organ failure: a retrospective case-matched study
Alternate Journal: Artificial organs
ISSN: 1525-1594 (Electronic)
Accession Number: 24020965
Abstract: Continuous venovenous hemofiltration (CVVH) is an important organ supportive technique. This study aimed to evaluate the impact of early classic CVVH on the outcomes of severe acute pancreatitis (SAP) patients with early organ failure (EOF). Between 2008 and 2012, a total of 44 SAP patients with EOF were admitted to our department. The 44 patients were classified into two groups according to whether they received early classic CVVH (2 L/h, initiated within 24 h after admission): 25 patients received early CVVH (ECVVH group), and 19 patients did not receive early CVVH (control group). The two groups were matched for age and Acute Physiology and Chronic Health Evaluation II scores. The severity of organ dysfunctions was evaluated by Sequential Organ Failure Assessment (SOFA) scores. Each group included 19 patients. The baseline characters between the two groups were balanced. The SOFA scores in the ECVVH group increased compared with those in the control group. The time to weaning from mechanical ventilation was significantly longer in the ECVVH group (log-rank test: chi(2) = 4.007, P = 0.045). Renal support was also significantly prolonged in the ECVVH group (the number of patients receiving CVVH 72 h after admission: 10 vs. 3, respectively, P = 0.038). Nine patients died in the ECVVH group versus six patients in the control group (P = 0.508). In conclusion, our study failed to prove that early classic CVVH had any benefits on the outcomes of SAP patients with EOF. Unexpectedly, early classic CVVH worsened organ functional capacity. However, it is possible that CVVH using advanced techniques may be beneficial in SAP patients with EOF.