November 12, 2014
Notes: Zhang, Hong-Wu
Deng, David Y B
Research Support, Non-U.S. Gov’t
Biomaterials. 2014 Jan;35(1):356-67. doi: 10.1016/j.biomaterials.2013.09.046. Epub 2013 Oct 5.
Author Address: Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, 58# Zhongshan 2nd Road, Guangzhou 510080, China.
Reference Type: Journal Article
Record Number: 4916Author: Zhang, T. T., Wang, L., Wang, D. B., Huang, Z. J., Li, Y. H. and Lu, J. P.
Title: Correlation between secretin-enhanced MRCP findings and histopathologic severity of chronic pancreatitis in a cat model
Short Title: Correlation between secretin-enhanced MRCP findings and histopathologic severity of chronic pancreatitis in a cat model
Alternate Journal: Pancreatology : official journal of the International Association of Pancreatology
ISSN: 1424-3911 (Electronic)
Accession Number: 24075513
Cholangiopancreatography, Magnetic Resonance/*methods
Disease Models, Animal
Abstract: BACKGROUND/OBJECTIVES: To evaluate the usefulness of secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) in chronic pancreatitis (CP), we compared the severity of disease determined histopathologically with that indicated by S-MRCP imaging parameters in an induced CP cat model. MATERIALS AND METHODS: An experimental group of randomly chosen cats (n = 24) underwent ligation of the pancreatic duct to induce CP, and cats in a similarly chosen control group (n = 8) were sham-operated. MRCP was performed prior to secretin stimulation, and 5 and 15 min afterward, noting in particular the pancreatic duct caliber change (PDC) and the increasing degree of fluid volume (IDFV). Histopathological changes were observed in pancreatic samples processed for hematoxylin-eosin and Sirius red staining, and CP was classified as normal, minimal, moderate, or advanced. Correlations were investigated between these groups and the PDC at 5 min and the IDFV at 15 min. RESULTS: Between cats with minimal CP and the controls, the differences in mean IDFV and PDC were not significant although diseased cats showed a downward trend in both parameters. However, compared with the control group both the mean IDFV and PDC were significantly lower in cats with moderate (IDFV, P = 0.001; PDC, P = 0.013) or advanced (IDFV, P = 0.013; PDC, P = 0.001) CP. CONCLUSION: The S-MRCP parameters IDFV and PDC correlated with the histopathological severity of induced CP. S-MRCP could be used to evaluate the severity of CP, although it is somewhat insensitive for depicting very early disease.