Pancreatitis

Notes: Zhang, Hong-Wu

Wang, Li-Qin

Xiang, Qing-Feng

Zhong, Qian

Chen, Lu-Ming

Xu, Cai-Xia

Xiang, Xian-Hong

Xu, Bo

Meng, Fei

Wan, Yi-Qian

Deng, David Y B

eng

Research Support, Non-U.S. Gov’t

Netherlands

2013/10/10 06:00

Biomaterials. 2014 Jan;35(1):356-67. doi: 10.1016/j.biomaterials.2013.09.046. Epub 2013 Oct 5.

URL: http://www.ncbi.nlm.nih.gov/pubmed/24103651

Author Address: Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, 58# Zhongshan 2nd Road, Guangzhou 510080, China.

 

 

Reference Type:  Journal Article

Record Number: 4916Author: Zhang, T. T., Wang, L., Wang, D. B., Huang, Z. J., Li, Y. H. and Lu, J. P.

Year: 2013

Title: Correlation between secretin-enhanced MRCP findings and histopathologic severity of chronic pancreatitis in a cat model

Journal: Pancreatology

Volume: 13

Issue: 5

Pages: 491-7

Date: Sep-Oct

Short Title: Correlation between secretin-enhanced MRCP findings and histopathologic severity of chronic pancreatitis in a cat model

Alternate Journal: Pancreatology : official journal of the International Association of Pancreatology

ISSN: 1424-3911 (Electronic)

1424-3903 (Linking)

DOI: 10.1016/j.pan.2013.08.003

Accession Number: 24075513

Keywords: Animals

Cats

Cholangiopancreatography, Magnetic Resonance/*methods

Disease Models, Animal

Female

Ligation

Male

Pancreatic Ducts/*pathology

Pancreatitis, Chronic/*pathology/physiopathology

Secretin/*diagnostic use

Abstract: BACKGROUND/OBJECTIVES: To evaluate the usefulness of secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) in chronic pancreatitis (CP), we compared the severity of disease determined histopathologically with that indicated by S-MRCP imaging parameters in an induced CP cat model. MATERIALS AND METHODS: An experimental group of randomly chosen cats (n = 24) underwent ligation of the pancreatic duct to induce CP, and cats in a similarly chosen control group (n = 8) were sham-operated. MRCP was performed prior to secretin stimulation, and 5 and 15 min afterward, noting in particular the pancreatic duct caliber change (PDC) and the increasing degree of fluid volume (IDFV). Histopathological changes were observed in pancreatic samples processed for hematoxylin-eosin and Sirius red staining, and CP was classified as normal, minimal, moderate, or advanced. Correlations were investigated between these groups and the PDC at 5 min and the IDFV at 15 min. RESULTS: Between cats with minimal CP and the controls, the differences in mean IDFV and PDC were not significant although diseased cats showed a downward trend in both parameters. However, compared with the control group both the mean IDFV and PDC were significantly lower in cats with moderate (IDFV, P = 0.001; PDC, P = 0.013) or advanced (IDFV, P = 0.013; PDC, P = 0.001) CP. CONCLUSION: The S-MRCP parameters IDFV and PDC correlated with the histopathological severity of induced CP. S-MRCP could be used to evaluate the severity of CP, although it is somewhat insensitive for depicting very early disease.

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