November 12, 2014
Notes: Zechner, Dietmar
Research Support, Non-U.S. Gov’t
Int J Clin Exp Pathol. 2013 Sep 15;6(10):2021-9. eCollection 2013.
Author Address: Institute for Experimental Surgery, University of Rostock Schillingallee 69a, 18057 Rostock, Germany.
Reference Type: Journal Article
Record Number: 5000Author: Zhang, D. Q., Feng, H. and Chen, W. C.
Title: Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat
Journal: Evid Based Complement Alternat Med
Short Title: Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat
Alternate Journal: Evidence-based complementary and alternative medicine : eCAM
ISSN: 1741-427X (Print)
Accession Number: 23983797
Abstract: Oxidative stress plays an important role in the pathogenesis of acute pancreatitis (AP). As an ideal exterminator of poisonous free radicals, hydrogen can clearly reduce the degree of oxidative damage caused by severe acute pancreatitis (SAP) and lessen the presence of inflammatory cytokines. The aim of this study was to investigate the effects and mechanism of hydrogen-rich saline on SAP in rats. Serum TNF- alpha , IL-6, and IL-18 and histopathological score in the pancreas were reduced after hydrogen-rich saline treatment. Malondialdehyde (MDA) and myeloperoxidase (MPO) contents were obviously reduced, while superoxide dismutase (SOD) and glutathione (GSH) contents were increased after hydrogen-rich saline treatment. The expression of mRNA of tumor necrosis factor- alpha (TNF- alpha ) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas was reduced in hydrogen-rich saline treated group. In conclusion, intravenous hydrogen-rich saline injections could attenuate the severity of AP, probably via inhibiting the oxidative stress and reducing the presence of inflammatory mediators.