November 12, 2014
Notes: Wang, Wei
BMJ Open. 2013 Sep 3;3(9):e003150. doi: 10.1136/bmjopen-2013-003150.
Author Address: Department of Gastroenterology, Changhai Hospital, The Second Military Medicine University, Shanghai, China.
Reference Type: Journal Article
Record Number: 4854Author: Wang, X., Xu, Y., Qiao, Y., Pang, X., Hong, L., Fu, J., Li, Y., Zhang, Z., Cui, Z., Li, H., Wang, W., Pang, H. and Zhang, W.
Title: An evidence-based proposal for predicting organ failure in severe acute pancreatitis
Short Title: An evidence-based proposal for predicting organ failure in severe acute pancreatitis
Alternate Journal: Pancreas
ISSN: 1536-4828 (Electronic)
Accession Number: 24152952
Keywords: Acute Disease
Aged, 80 and over
Inpatients/*statistics & numerical data
Multiple Organ Failure/blood/complications/*diagnosis
Severity of Illness Index
Tomography, X-Ray Computed
Abstract: OBJECTIVES: Early, efficient, and accurate evaluation for organ failure is an important step for improving outcome in severe acute pancreatitis (SAP). We aim to develop a method that can early, efficiently, and accurately evaluate the in-hospital organ failure in patients with SAP. METHODS: Using multivariate logistic regression analysis, the associative factors for in-hospital organ failure were evaluated retrospectively from conventional data obtained from 393 patients with SAP from 2000 to 2012. In classification and regression tree analysis, a new clinical scoring system was developed for the evaluation of in-hospital organ failure in SAP. We also compared the accuracy of our new scoring system with multiple organ dysfunction score and Acute Physiology and Chronic Health Examination II score by the receiver operating characteristic curve. RESULTS: Laboratory results revealed serum calcium level greater than or equal to 1.84 mmol/L, serum creatinine level greater than or equal to 110 micromol/L, age greater than or equal to 72 years, activated partial thromboplastin time less than or equal to 30.95 seconds, and Balthazar computed tomography score greater than or equal to 7 (CCAAB) score system, each contributed 1 point for the prediction of organ failure. The area under the curve of the CCAAB score system was similar to multiple organ dysfunction scores and Acute Physiology and Chronic Health Examination II scores. CONCLUSIONS: The new scoring system CCAAB is an efficient and accurate method for the early evaluation of patients with SAP for in-hospital organ failure.