November 12, 2014
Notes: Sun, Yanmei
Int J Clin Exp Pathol. 2013 Jul 15;6(8):1696-701. Print 2013.
Author Address: Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430060, China.
Reference Type: Journal Article
Record Number: 5074Author: Takacs, T., Rosztoczy, A., Maleth, J., Rakonczay, Z., Jr. and Hegyi, P.
Title: Intraductal acidosis in acute biliary pancreatitis
Short Title: Intraductal acidosis in acute biliary pancreatitis
Alternate Journal: Pancreatology : official journal of the International Association of Pancreatology
ISSN: 1424-3911 (Electronic)
Accession Number: 23890129
Cholangiopancreatography, Endoscopic Retrograde
Abstract: Acute pancreatitis recently became the most common cause for hospitalization among gastrointestinal diseases. There is no specific therapy against the disease due to insufficient understanding of pathogenesis. Animal and in vitro models indicated that reduced pancreatic ductal bicarbonate secretion and consequent intraductal acidosis is an early event in acute pancreatitis, but human data are lacking. Therefore, our aim was to determine the luminal pH in the main pancreatic duct during acute pancreatitis in humans. Intraductal pH was measured in patients with acute biliary pancreatitis (n = 6) during endoscopic retrograde cholangio-pancreatography. Patients with common bile stones without pancreatitis (n = 5) and a patient with an adenoma of the papilla of Vater served as controls. The luminal pH was significantly lower in the group of acute biliary pancreatitis vs. controls (6.97 +/- 0.13 vs. 7.79 +/- 0.20). Our brief report shows for the first time that there is marked intraductal acidosis in acute biliary pancreatitis, which seems to worsen with time. Further clinical trials are needed to determine the exact roles of reduced intraductal pH in ABP.