November 12, 2014
Bruno, Marco J
Research Support, Non-U.S. Gov’t
Best Pract Res Clin Gastroenterol. 2013 Oct;27(5):727-43. doi: 10.1016/j.bpg.2013.08.007. Epub 2013 Sep 6.
Author Address: Department of Operation Rooms, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: firstname.lastname@example.org.
Reference Type: Journal Article
Record Number: 4900Author: Seo, J. H., Lee da, Y., Hong, C. W., Lee, I. H., Ahn, K. S. and Kang, G. W.
Title: Severe lactic acidosis and acute pancreatitis associated with cimetidine in a patient with type 2 diabetes mellitus taking metformin
Journal: Intern Med
Short Title: Severe lactic acidosis and acute pancreatitis associated with cimetidine in a patient with type 2 diabetes mellitus taking metformin
Alternate Journal: Internal medicine
ISSN: 1349-7235 (Electronic)
Accession Number: 24088760
Keywords: Acidosis, Lactic/*chemically induced/diagnosis
Aged, 80 and over
Cimetidine/administration & dosage/*adverse effects
Diabetes Mellitus, Type 2/complications/*drug therapy
Drug Therapy, Combination
Hypoglycemic Agents/administration & dosage/adverse effects
Metformin/administration & dosage/*adverse effects
*Severity of Illness Index
Abstract: An 82-year-old woman with type 2 diabetes mellitus, hypertension, and unstable angina presented with severe lactic acidosis and acute kidney injury (AKI) accompanied by acute pancreatitis. Her medical history revealed that she had taken cimetidine for two weeks while taking other medications, including metformin. Continuous veno-venous hemodiafiltration (CVVHDF) was initiated under diagnosis of lactic acidosis due to metformin and AKI caused by cimetidine-induced acute pancreatitis. In three days of CVVHDF, the levels of serum biochemical markers of lactic acidosis and AKI improved and the patient’s urine output reached over 1 L/day. The pancreatitis improved over time.