November 12, 2014
Title: Chronic pancreatitis: a path to pancreatic cancer
Journal: Cancer Lett
Date: Apr 10
Short Title: Chronic pancreatitis: a path to pancreatic cancer
Alternate Journal: Cancer letters
ISSN: 1872-7980 (Electronic)
Accession Number: 23981573
Anti-Inflammatory Agents/therapeutic use
Anticarcinogenic Agents/therapeutic use
Antineoplastic Agents/therapeutic use
Carcinoma, Pancreatic Ductal/drug
therapy/*etiology/immunology/metabolism/prevention & control
Cell Transformation, Neoplastic/immunology/metabolism
Pancreatic Neoplasms/drug therapy/*etiology/immunology/metabolism/prevention &
Pancreatitis, Chronic/*complications/drug therapy/immunology/metabolism
Abstract: Chronic pancreatitis predisposes to pancreatic cancer development and both diseases share a common etiology. A central role has been proposed for the digestive enzyme-secreting acinar cell that can undergo ductal metaplasia in the inflammatory environment of pancreatitis. This metaplastic change is now a recognised precursor of pancreatic cancer. Inflammatory molecules also foster tumour growth through autocrine and paracrine effects in the epithelium and the stroma. These insights have raised new opportunities such as the manipulation of inflammation as a preventive and/or therapeutic strategy for pancreatic cancer. Finally, we address the need for an in-depth study of the pancreatic acinar cells.
Notes: Pinho, Andreia V
Cancer Lett. 2014 Apr 10;345(2):203-9. doi: 10.1016/j.canlet.2013.08.015. Epub 2013 Aug 24.
Author Address: Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia.
Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia; Macarthur Cancer Therapy Centre, Campbelltown Hospital, Campbelltown, Australia.
Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia; St. Vincent’s Clinical School, University of New South Wales, Sydney, Australia; Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: email@example.com.