November 12, 2014
Notes: Oskarsson, Viktor
Research Support, Non-U.S. Gov’t
Clin Gastroenterol Hepatol. 2014 Apr;12(4):676-82. doi: 10.1016/j.cgh.2013.09.058. Epub 2013 Oct 5.
Author Address: Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: email@example.com.
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Gastrointestinal Surgery, Karolinska University Hospital, Stockholm, Sweden.
Reference Type: Journal Article
Record Number: 4876Author: Otsuki, M., Takeda, K., Matsuno, S., Kihara, Y., Koizumi, M., Hirota, M., Ito, T., Kataoka, K., Kitagawa, M., Inui, K. and Takeyama, Y.
Title: Criteria for the diagnosis and severity stratification of acute pancreatitis
Journal: World J Gastroenterol
Date: Sep 21
Short Title: Criteria for the diagnosis and severity stratification of acute pancreatitis
Alternate Journal: World journal of gastroenterology : WJG
ISSN: 2219-2840 (Electronic)
Accession Number: 24124324
Keywords: Acute Disease
Contrast Media/diagnostic use
*Decision Support Techniques
Predictive Value of Tests
Severity of Illness Index
Tomography, X-Ray Computed
Abstract: Recent diagnostic and therapeutic progress for severe acute pancreatitis (SAP) remarkably decreased the case-mortality rate. To further decrease the mortality rate of SAP, it is important to precisely evaluate the severity at an early stage, and initiate appropriate treatment as early as possible. Research Committee of Intractable Diseases of the Pancreas in Japan developed simpler criteria combining routinely available data with clinical signs. Severity can be evaluated by laboratory examinations or by clinical signs, reducing the defect values of the severity factors. Moreover, the severity criteria considered laboratory/clinical severity scores and contrast-enhanced computed tomography (CE-CT) findings as independent risk factors. Thus, CE-CT scans are not necessarily required to evaluate the severity of acute pancreatitis. There was no fatal case in mild AP diagnosed by the CE-CT severity score, whereas case-mortality rate in those with SAP was 14.8%. Case-mortality of SAP that fulfilled both the laboratory/clinical and the CE-CT severity criteria was 30.8%. It is recommended, therefore, to perform CE-CT examination to clarify the prognosis in those patients who were diagnosed as SAP by laboratory/clinical severity criteria. Because the mortality rate of these patients with SAP is high, such patients should be transferred to advanced medical units.