November 12, 2014
Notes: Matone, Jacques
Moretti, Ana Iochabel Soares
Apodaca-Torrez, Franz Robert
Research Support, Non-U.S. Gov’t
Acta Cir Bras. 2013 Aug;28(8):559-67.
Author Address: Postgraduate Program in Gastrointestinal Surgery, Federal University of Sao Paulo – Paulista Medical School, Sao Paulo, Brazil. email@example.com
Reference Type: Journal Article
Record Number: 5051Author: Matsubayashi, H., Yoneyama, M., Nanri, K., Sugimoto, S., Shinjo, K., Kakushima, N., Tanaka, M., Ito, S., Takao, M. and Ono, H.
Title: Determination of steroid response by abdominal ultrasound in cases with autoimmune pancreatitis
Journal: Dig Liver Dis
Short Title: Determination of steroid response by abdominal ultrasound in cases with autoimmune pancreatitis
Alternate Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562 (Electronic)
Accession Number: 23906519
Autoimmune Diseases/blood/*drug therapy/*ultrasonography
Steroids/administration & dosage/*therapeutic use
Abstract: BACKGROUND: Abdominal ultrasound is the most convenient modality for examining the morphology of the pancreas without physical stress. Steroid response is one of the key features of autoimmune pancreatitis; however, visualizing this response has not been evaluated using ultrasonography. METHODS: Thirty-three consecutive autoimmune pancreatitis cases were retrospectively investigated for pancreatic and extrapancreatic lesions by ultrasonography before steroid therapy (n=33) and at two weeks (n=28) and one month (n=19) after starting oral steroid treatment. RESULTS: Steroid treatment resulted in obvious shrinkage of the pancreatic lesion in 86% of the cases at two weeks and in 97% until one month. The maximum thickness of the pancreatic lesion was reduced from 28 to 22 mm in two weeks (P<0.0001), and pancreatic echographic findings improved in one month. Swelling of the peripancreatic lymph node was recognized in 48% and the aortic wall thickness in 12%, mostly reduced in two weeks (P=0.005). One case of definitive autoimmune pancreatitis revealed a steroid response only by following endoscopic retrograde cholangiopancreatography but not by ultrasonography or computed tomography. CONCLUSIONS: Abdominal ultrasound revealed a steroid response in most cases of autoimmune pancreatitis within two weeks. Ultrasonography is suitable for initial confirmation of a steroid response; however, atypical cases showing insufficient response or not fulfilling criteria should undergo further examination.