November 12, 2014
Notes: Lytvynenko, O M
Homoliako, I V
Kaliuzhka, A S
Klin Khir. 2013 Apr;(4):28-31.
Reference Type: Journal Article
Record Number: 4843Author: Ma, X., Zhao, X., Ouyang, H., Sun, F., Zhang, H. and Zhou, C.
Title: Quantified ADC histogram analysis: a new method for differentiating mass-forming focal pancreatitis from pancreatic cancer
Journal: Acta Radiol
Short Title: Quantified ADC histogram analysis: a new method for differentiating mass-forming focal pancreatitis from pancreatic cancer
Alternate Journal: Acta radiologica
ISSN: 1600-0455 (Electronic)
Accession Number: 24167322
Diffusion Magnetic Resonance Imaging/*methods
Image Interpretation, Computer-Assisted/*methods
Numerical Analysis, Computer-Assisted
Reproducibility of Results
Sensitivity and Specificity
Abstract: BACKGROUND: As their prognosis and management are different, differentiation of mass-forming focal pancreatitis (FP) from pancreatic adenocarcinoma (PC) is important. However, the similar clinical presentations and imaging features of these conditions, along with inconclusive biopsy results can make such differentiation difficult. PURPOSE: To determine whether apparent diffusion coefficient (ADC) histogram analysis can discriminate between a normal pancreas, FP, and PC. MATERIAL AND METHODS: In a retrospective study, 25 PC patients, 14 FP patients, and 25 subjects with a normal pancreas underwent breath-hold diffusion-weighted imaging (DWI) on a 3.0 T magnetic resonance (MR) scanner. Regions of interest (ROIs) were drawn on the normal pancreases and on the entire focal lesions of both PC and FP. The ADC value was averaged from the lowest to 10th, 30th, 50th, and 100th percentile of the histogram (i.e. ADC10, ADC30, ADC50, and ADC100, respectively), and the results were analyzed statistically. RESULTS: There were no significant differences among the head, body, and tail of normal pancreases for any of the mean ADC values (P > 0.05). ADC10, ADC30, and ADC50 values demonstrated significant differences between lesion and non-lesion areas of both PC (P < 0.05) and FP (P < 0.05). Differences in lesion areas between PC and FP were found with ADC50 and ADC100 values (P < 0.05), and helped differentiate a normal pancreas from FP and PC, and FP from PC. CONCLUSION: Quantified ADC histogram can specifically reflect tissue heterogeneity and help differentiate a normal pancreas from FP and PC.