November 12, 2014
Author Address: Department of Microbiology, Kyoto University Graduate School of Medicine, Kyoto, Japan. firstname.lastname@example.org
Reference Type: Journal Article
Record Number: 4936Author: Kusnierz-Cabala, B., Gurda-Duda, A., Dumnicka, P., Kuzniewski, M., Kulig, J., Panek, J. and Solnica, B.
Title: [Analysis of selected inflammatory markers for early prediction of severe clinical course of acute pancreatitis]
Journal: Przegl Lek
Short Title: [Analysis of selected inflammatory markers for early prediction of severe clinical course of acute pancreatitis]
Alternate Journal: Przeglad lekarski
ISSN: 0033-2240 (Print)
Original Publication: Znaczenie wybranych markerow zapalnych dla wczesnego przewidywania ciezkosci przebiegu ostrego zapalenia trzustki.
Accession Number: 24052976
Keywords: Acute-Phase Proteins/*analysis
Serum Amyloid A Protein/*analysis
Abstract: Despite new diagnostic methods, including novel laboratory parameters and imaging techniques, and growing knowledge on pathogenesis of acute pancreatitis, early assessment of severity remains the main factor influencing prognosis in the disease. The aim of the study was the evaluation of diagnostic accuracy of interleukins (IL): 6 and 18 and acute phase proteins: C-reactive protein (CRP) and serum amyloid A (SAA), together with Glasgow prognostic score during first 48 hours after diagnosing acute pancreatitis in a group of 40 patients treated in the I-st Department of General and Gastrointestinal Surgery University Hospital in Cracow. All the studied inflammatory markers were significantly higher in patients with moderate and severe acute pancreatitis versus patients with mild form of the disease on the first 48 hours of the disease. Expanding Glasgow score with IL-6, IL-18, SAA or CRP determinations resulted in better accuracy for diagnosing severe clinical course of acute pancreatitis.