November 12, 2014
Notes: Brock, Christina
Nielsen, Lecia Moller
Drewes, Asbjorn Mohr
Research Support, Non-U.S. Gov’t
World J Gastroenterol. 2013 Nov 14;19(42):7231-40. doi: 10.3748/wjg.v19.i42.7231.
Author Address: Christina Brock, Lecia Moller Nielsen, Dina Lelic, Asbjorn Mohr Drewes, Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, DK-9000 Aalborg, Denmark.
Reference Type: Journal Article
Record Number: 4623Author: Buddingh, K. T., Koudstaal, L. G., van Santvoort, H. C., Besselink, M. G., Timmer, R., Rosman, C., van Goor, H., Nijmeijer, R. M., Gooszen, H., Leuvenink, H. G., Ploeg, R. J. and Nieuwenhuijs, V. B.
Title: Early angiopoietin-2 levels after onset predict the advent of severe pancreatitis, multiple organ failure, and infectious complications in patients with acute pancreatitis
Journal: J Am Coll Surg
Short Title: Early angiopoietin-2 levels after onset predict the advent of severe pancreatitis, multiple organ failure, and infectious complications in patients with acute pancreatitis
Alternate Journal: Journal of the American College of Surgeons
ISSN: 1879-1190 (Electronic)
Accession Number: 24355874
Keywords: Acute Disease
Bacterial Infections/blood/*diagnosis/etiology/prevention & control
Decision Support Techniques
Enzyme-Linked Immunosorbent Assay
Multiple Organ Failure/blood/*diagnosis/etiology/prevention & control
Pancreatitis, Acute Necrotizing/blood/diagnosis/mortality/prevention & control
Predictive Value of Tests
*Severity of Illness Index
Abstract: BACKGROUND: Acute pancreatitis is a severe condition that requires early identification of patients at risk of developing potentially lethal complications. Current clinical scoring systems and biochemical parameters are insufficient. In this study, we aimed to assess whether early plasma Angiopoietin-2 (Ang-2) is associated with adverse outcomes in patients with predicted severe acute pancreatitis (SAP). STUDY DESIGN: This analysis is a substudy of the PROPATRIA trial (probiotics vs placebo in patients with predicted SAP). The Ang-2 levels were measured prospectively in plasma in the first 5 days after admission in 115 patients. RESULTS: Early Ang-2 levels were higher in patients who developed SAP: 6.4 vs 3.1 mug/L (p < 0.001) and also were higher in patients who developed multiorgan failure in the first week (p = 0.001) and after the first week (p = 0.049). Furthermore, high Ang-2 levels were associated with infectious complications in the first week (p < 0.001) and after the first week (p < 0.001). Finally, plasma Ang-2 was significantly higher in patients who died (p < 0.001) and in patients who developed bowel ischemia (p < 0.001). As a predictor of adverse outcomes, plasma Ang-2 was superior to a number of current scores, such as the APACHE II score, the Imrie score, C-reactive protein, lipopolysaccharide binding protein, and procalcitonin. CONCLUSIONS: In the setting of this randomized controlled trial, early plasma Ang-2 was found to be an accurate predictor of SAP, multiorgan failure, and infectious complications. As a biomarker, it did outperform all of the investigated conventional predictors that are currently used in clinical practice.