November 12, 2014
Notes: Bozkurt, Suleyman
Turk J Gastroenterol. 2013;24(6):469-75.
Author Address: Bezmialem Vakif University School of Medicine, Department of General Surgery, Fatih, Istanbul, Turkey.
Reference Type: Journal Article
Record Number: 4622Author: Brock, C., Nielsen, L. M., Lelic, D. and Drewes, A. M.
Title: Pathophysiology of chronic pancreatitis
Journal: World J Gastroenterol
Date: Nov 14
Short Title: Pathophysiology of chronic pancreatitis
Alternate Journal: World journal of gastroenterology : WJG
ISSN: 2219-2840 (Electronic)
Accession Number: 24259953
Keywords: Alcohol Drinking/adverse effects/epidemiology
Genetic Predisposition to Disease
Abstract: Chronic pancreatitis (CP) is an inflammatory disease of the pancreas characterized by progressive fibrotic destruction of the pancreatic secretory parenchyma. Despite the heterogeneity in pathogenesis and involved risk factors, processes such as necrosis/apoptosis, inflammation or duct obstruction are involved. This fibrosing process ultimately leads to progressive loss of the lobular morphology and structure of the pancreas, deformation of the large ducts and severe changes in the arrangement and composition of the islets. These conditions lead to irreversible morphological and structural changes resulting in impairment of both exocrine and endocrine functions. The prevalence of the disease is largely dependent on culture and geography. The etiological risk-factors associated with CP are multiple and involve both genetic and environmental factors. Throughout this review the M-ANNHEIM classification system will be used, comprising a detailed description of risk factors such as: alcohol-consumption, nicotine-consumption, nutritional factors, hereditary factors, efferent duct factors, immunological factors and miscellaneous and rare metabolic factors. Increased knowledge of the different etiological factors may encourage the use of further advanced diagnostic tools, which potentially will help clinicians to diagnose CP at an earlier stage. However, in view of the multi factorial disease and the complex clinical picture, it is not surprising that treatment of patients with CP is challenging and often unsuccessful.