November 12, 2014
Notes: Cicek, Bahattin
Turk J Gastroenterol. 2013;24(2):173-7.
Author Address: Acibadem University, School of Medicine, Department of Gastroenterology, Istanbul, Turkey. email@example.com
Reference Type: Journal Article
Record Number: 5062Author: Closa, D.
Title: Free radicals and acute pancreatitis: much ado about … something
Journal: Free Radic Res
Short Title: Free radicals and acute pancreatitis: much ado about … something
Alternate Journal: Free radical research
ISSN: 1029-2470 (Electronic)
Accession Number: 23895210
Keywords: Acute Disease
Pancreatitis, Acute Necrotizing/metabolism
Reactive Oxygen Species/metabolism
Abstract: There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic damage. Oxidative stress is also involved in the progression of the disease from a local damage to a systemic organ failure. However, therapeutic use of antioxidants failed to clearly show a clinical benefit in different trials. Therefore, although antioxidants alone seem to be not enough for the treatment of severe acute pancreatitis, future combined therapeutic strategies should include antioxidants in its composition.
Notes: Closa, Daniel
Free Radic Res. 2013 Nov;47(11):934-40. doi: 10.3109/10715762.2013.829571. Epub 2013 Oct 4.