November 12, 2014
Notes: Camargo, E A
Santana, D G
Silva, C I
Teixeira, S A
Toyama, M H
Landucci, E C T
Muscara, M N
Costa, S K P
Eur J Pain. 2014 May;18(5):691-700. doi: 10.1002/j.1532-2149.2013.00414.x. Epub 2013 Oct 24.
Author Address: Department of Physiology, Federal University of Sergipe, Sao Cristovao, Brazil.
Reference Type: Journal Article
Record Number: 5065Author: Cekic, A. B., Alhan, E., Usta, A., Turkyilmaz, S., Kural, B. V. and Ercin, C.
Title: Effects of clotrimazol on the acute necrotizing pancreatitis in rats
Short Title: Effects of clotrimazol on the acute necrotizing pancreatitis in rats
Alternate Journal: Inflammation
ISSN: 1573-2576 (Electronic)
Accession Number: 23892997
Keywords: 14-alpha Demethylase Inhibitors/*therapeutic use
Blood Pressure/drug effects
Bronchoalveolar Lavage Fluid/chemistry
Disease Models, Animal
Pancreatitis, Acute Necrotizing/chemically induced/*drug therapy/mortality
Abstract: This study aims to investigate the influence of clotrimazol (CLTZ) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. Rats were divided into five groups as sham + saline, sham + CLTZ, sham + polyethylene glycol, ANP + saline, and ANP + CLTZ. ANP in rats was induced by glycodeoxycholic acid. The extent of acinar cell injury, mortality, systemic cardiorespiratory variables, functional capillary density (FCD), renal/hepatic functions, and changes in some enzyme markers for pancreatic and lung tissue were investigated during ANP in rats. The use of CLTZ after the induction of ANP resulted in a significant decrease in the mortality rate, pancreatic necrosis, and serum activity of amylase, alanine aminotransferase, interleukin-6, lactate dehydrogenase in bronchoalveolar lavage fluid, serum concentration of urea, and tissue activity of myeloperoxidase, and malondialdehyde in the pancreas and lung and a significant increase in concentrations of calcium, blood pressure, urine output, pO2, and FCD. This study showed that CLTZ demonstrated beneficial effect on the course of ANP in rats. Therefore, it may be used in the treatment of acute pancreatitis.