November 12, 2014
Notes: Anyfantakis, D
J Med Life. 2013 Sep 15;6(3):332-5. Epub 2013 Sep 25.
Author Address: Primary Health Care Centre of Kissamos, Chania, Crete, Greece.
Reference Type: Journal Article
Record Number: 5019Author: Armstrong, J. A., Cash, N., Soares, P. M., Souza, M. H., Sutton, R. and Criddle, D. N.
Title: Oxidative stress in acute pancreatitis: lost in translation?
Journal: Free Radic Res
Short Title: Oxidative stress in acute pancreatitis: lost in translation?
Alternate Journal: Free radical research
ISSN: 1029-2470 (Electronic)
Accession Number: 23952531
Keywords: Acute Disease
Pancreatitis, Acute Necrotizing/metabolism
Abstract: Oxidative stress has been implicated in the pathogenesis of acute pancreatitis, a severe and debilitating inflammation of the pancreas that carries a significant mortality, and which imposes a considerable financial burden on the health system due to patient care. Although extensive efforts have been directed towards the elucidation of critical underlying mechanisms and the identification of novel therapeutic targets, the disease remains without a specific therapy. In experimental animal models of acute pancreatitis, increased oxidative stress and decreased antioxidant defences have been observed, changes also detected in patients clinically. However, despite the promise of studies evaluating the effects of antioxidants in these model systems, translation to the clinic has thus far been disappointing. This may reflect many factors involved in the design of both preclinical and clinical evaluations of antioxidant therapy, not least the fact that most experimental studies have focussed on pre-treatment rather than post-injury assessment. This review has examined evidence relating to the involvement of oxidative stress in the pathophysiology of acute pancreatitis, focussing on experimental models and the clinical experience, including the experimental techniques employed and potential of antioxidant therapy.