November 12, 2014
Notes: Berglund, Lars
Brunzell, John D
Goldberg, Anne C
Goldberg, Ira J
UL1 TR000002/TR/NCATS NIH HHS/
Best Pract Res Clin Endocrinol Metab. 2014 Jun;28(3):423-37. doi: 10.1016/j.beem.2013.10.002. Epub 2013 Oct 17.
Author Address: Department of Medicine, University of California, Davis, CA, USA; Department of Veterans Affairs, Northern California Health Care System, 2921 Stockton Blvd, Suite 1400, Sacramento, CA 95817, USA. Electronic address: email@example.com.
Department of Medicine, University of Washington, School of Medicine, 1959 NE Pacific Street, UW Mailbox 356426, Seattle, WA 98195-6426, USA. Electronic address: JBrunzell@medicine.washington.edu.
Department of Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid, St. Louis, MO 63110, USA. Electronic address: firstname.lastname@example.org.
Department of Medicine, Columbia University, Presbyterian Hospital, PH 10-305, 622 West 168th Street, New York, NY 10032, USA. Electronic address: email@example.com.
Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Electronic address: A.Stalenhoef@aig.umcn.nl.
Reference Type: Journal Article
Record Number: 4617Author: Beyer, G., Menzel, J., Kruger, P. C., Ribback, S., Lerch, M. M. and Mayerle, J.
Title: [Autoimmune pancreatitis]
Journal: Dtsch Med Wochenschr
Pages: 2359-70; quiz 2371-4
Short Title: [Autoimmune pancreatitis]
Alternate Journal: Deutsche medizinische Wochenschrift
ISSN: 1439-4413 (Electronic)
Original Publication: Autoimmunpankreatitis.
Accession Number: 24193862
Keywords: Autoimmune Diseases/*diagnosis/*drug therapy
Immunosuppressive Agents/*therapeutic use
Abstract: Autoimmune pancreatitis is a relatively rare form of chronic pancreatitis which is characterized by a lymphoplasmatic infiltrate with a storiform fibrosis and often goes along with painless jaundice and discrete discomfort of the upper abdomen. Clinically we distinguish between two subtypes, which differ in terms of their histology, clinical picture and prognosis. Type 1 autoimmune pancreatitis is the pancreatic manifestation of the IgG4-associated syndrome which also involves other organs. About one third of the patients can only be diagnosed after either histological prove or a successful steroid trail. Type 2 is IgG4-negative with the histological picture of an idiopathic duct centric pancreatitis and is to higher degree associated with inflammatory bowel disease. A definitive diagnosis can only be made using biopsy. Usually both forms show response to steroid treatment, but in type 1 up to 50 % of the patients might develop a relapse. The biggest challenge and most important differential diagnosis remains the discrimination of AIP from pancreatic cancer, because also AIP can cause mass of the pancreatic head, lymphadenopathy and ductal obstruction. This article summarizes recent advances on epidemiology, clinical presentation, diagnostic strategy, therapy and differential diagnosis in this relatively unknown disease.