November 12, 2014
Notes: Zhang, Xiao-Ying
Research Support, Non-U.S. Gov’t
Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 Nov;44(6):974-7, 986.
Author Address: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Reference Type: Journal Article
Record Number: 4838Author: Zhao, J. B., Liao, D. H. and Nissen, T. D.
Title: Animal models of pancreatitis: can it be translated to human pain study?
Journal: World J Gastroenterol
Date: Nov 14
Short Title: Animal models of pancreatitis: can it be translated to human pain study?
Alternate Journal: World journal of gastroenterology : WJG
ISSN: 2219-2840 (Electronic)
Accession Number: 24259952
Keywords: Abdominal Pain/*etiology/physiopathology/psychology/therapy
Disease Models, Animal
*Translational Medical Research
Abstract: Chronic pancreatitis affects many individuals around the world, and the study of the underlying mechanisms leading to better treatment possibilities are important tasks. Therefore, animal models are needed to illustrate the basic study of pancreatitis. Recently, animal models of acute and chronic pancreatitis have been thoroughly reviewed, but few reviews address the important aspect on the translation of animal studies to human studies. It is well known that pancreatitis is associated with epigastric pain, but the understanding regarding to mechanisms and appropriate treatment of this pain is still unclear. Using animal models to study pancreatitis associated visceral pain is difficult, however, these types of models are a unique way to reveal the mechanisms behind pancreatitis associated visceral pain. In this review, the animal models of acute, chronic and un-common pancreatitis are briefly outlined and animal models related to pancreatitis associated visceral pain are also addressed.