November 12, 2014
Notes: Xue, Jing
DK092421/DK/NIDDK NIH HHS/
DK56339/DK/NIDDK NIH HHS/
R01 DK092421/DK/NIDDK NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov’t
J Clin Invest. 2014 Jan 2;124(1):437-47. doi: 10.1172/JCI71362. Epub 2013 Dec 16.
Reference Type: Journal Article
Record Number: 4828Author: Yang, J., Shao, Q. S., Xu, J., Yu, X. J., Xu, Y., Tao, H. Q. and Yao, H. B.
Title: [Timing and efficacy of surgical intervention for severe acute pancreatitis]
Journal: Zhonghua Yi Xue Za Zhi
Short Title: [Timing and efficacy of surgical intervention for severe acute pancreatitis]
Alternate Journal: Zhonghua yi xue za zhi
ISSN: 0376-2491 (Print)
Accession Number: 24534352
Pancreatitis, Acute Necrotizing/*surgery
Abstract: OBJECTIVE: To explore the indications, timing and approaches of surgical interventions for severe acute pancreatitis (SAP). METHODS: A retrospective study was performed for 115 hospitalized SAP patients from 2007 to 2013. RESULTS: Among them, 62 underwent surgery and another 53 were treated conservatively. The curative and mortality rates of surgical intervention and non-operation groups were 87.1%vs 84.9% (P > 0.05) and 9.68% vs 9.43% (P > 0.05) respectively. Twenty-five patients received early surgical intervention (<2 week) and another 37 delayed surgical intervention. The interval from diagnosis to surgical intervention of two groups were 7.5 +/- 3.3 and 23.9 +/- 8.5 days respectively. The mortality rates of early and delayed surgical groups were 16.0% and 5.4% respectively (P > 0.05). CONCLUSIONS: Individualized comprehensive therapy should be offered in the treatment of SAP. Timing of surgery for those with pancreatic necrosis and infection should be delayed to 3-4 weeks later until their general conditions permit.