November 12, 2014
Notes: Tian, Rui
Research Support, Non-U.S. Gov’t
World J Gastroenterol. 2013 Dec 7;19(45):8282-91. doi: 10.3748/wjg.v19.i45.8282.
Author Address: Rui Tian, Rui-Lan Wang, Hui Xie, Wei Jin, Kang-Long Yu, Intensive Care Unit, First People’s Hospital, Shanghai Jiaotong University, Shanghai 201620, China.
Reference Type: Journal Article
Record Number: 4798Author: Tieftrunk, E., Demir, I. E., Simon, P., Friess, H. and Ceyhan, G. O.
Title: Evidence of pancreatic neuropathy and neuropathic pain in hereditary chronic pancreatitis
Short Title: Evidence of pancreatic neuropathy and neuropathic pain in hereditary chronic pancreatitis
Alternate Journal: Pancreatology : official journal of the International Association of Pancreatology
ISSN: 1424-3911 (Electronic)
Accession Number: 24280582
Magnetic Resonance Imaging
Peripheral Nervous System Diseases/*etiology
Abstract: Increased neural density and neural hypertrophy are characteristic features of pancreatic neuropathy in chronic pancreatitis. Here, we present the extraordinary case of prominent pancreatic neuropathy in a 21-year-old female patient with hereditary chronic pancreatitis and intractable pain who underwent total pancreatectomy. The histopathological analysis demonstrated remnant pancreatic tissue which was only composed of prominent intrapancreatic nerves and fibrosis, without any visible remaining functional pancreatic parenchyma. These histological alterations, including nerve hypertrophy and increased neural density, are known for different aetiologies of chronic pancreatitis, e.g. alcoholic, idiopathic and tropic pancreatitis. However, this is the first report of a patient with hereditary chronic pancreatitis demonstrating the characteristic features of pancreatic neuropathy and neuropathic pain.