November 12, 2014
Notes: Sun, Hong-Li
Surgeon. 2014 Jun;12(3):141-7. doi: 10.1016/j.surge.2013.10.010. Epub 2013 Dec 9.
Author Address: Department of Biliary Vascular Surgery, Shenjing Hospital of China Medical University, Shenyang 110004, China.
Department of General Surgery, Central Hospital of Shenyang Medical College, Shenyang 110004, China.
Department of Biliary Vascular Surgery, Shenjing Hospital of China Medical University, Shenyang 110004, China. Electronic address: firstname.lastname@example.org.
Reference Type: Journal Article
Record Number: 4788Author: Sun, J. J., Chu, Z. J., Liu, W. F., Qi, S. F., Yang, Y. H., Ge, P. L., Zhang, X. H., Li, W. S., Yang, C. and Zhang, Y. M.
Title: Perirenal space blocking restores gastrointestinal function in patients with severe acute pancreatitis
Journal: World J Gastroenterol
Date: Dec 14
Short Title: Perirenal space blocking restores gastrointestinal function in patients with severe acute pancreatitis
Alternate Journal: World journal of gastroenterology : WJG
ISSN: 2219-2840 (Electronic)
Accession Number: 24379596
Keywords: Abdominal Pain/etiology/therapy
Anesthetics, Local/*administration & dosage
Lidocaine/*administration & dosage
Recovery of Function
Severity of Illness Index
Abstract: AIM: To investigate effects of perirenal space blocking (PSB) on gastrointestinal function in patients with severe acute pancreatitis (SAP). METHODS: Forty patients with SAP were randomly allocated to receive PSB or no PSB (NPSB). All the SAP patients received specialized medical therapy (SMT). Patients in the PSB group received PSB + SMT when hospitalized and after diagnosis, whereas patients in the NPSB group only received SMT. A modi fi ed gastrointestinal failure (GIF) scoring system was used to assess the gastrointestinal function in SAP patients after admission. Pain severity (visual analog scale, 0 to 100) was monitored every 24 h for 72 h. RESULTS: Modified GIF score decreased in both groups during the 10-d study period. The median score decrease was initially significantly greater in the PSB group than in the NPSB group after PSB was performed. During the 72-h study period, pain intensity decreased in both groups. The median pain decrease was significantly greater in the PSB group than in the NPSB group at single time points. Patients in the PSB group had significantly lower incidences of hospital mortality, multiple organ dysfunction syndrome, systemic inflammatory response syndrome, and pancreatic infection, and stayed in the intensive care unit for a shorter duration. However, no difference in terms of operation incidence was found between the two groups. CONCLUSION: PSB could ameliorate gastrointestinal dysfunction or failure during the early stage of SAP. Moreover, PSB administration could improve prognosis and decrease the mortality of SAP patients.