November 12, 2014
Nihon Shokakibyo Gakkai Zasshi. 2013 Nov;110(11):1983-8.
Author Address: Department of Gastroenterological Surgery (Department of Surgery II) , Nagoya University Graduate School of Medicine.
Reference Type: Journal Article
Record Number: 4785Author: Suguna, P., Geetha, A., Aruna, R. and Siva, G. V.
Title: Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis–a dose response study in rats
Journal: Indian J Exp Biol
Short Title: Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis–a dose response study in rats
Alternate Journal: Indian journal of experimental biology
ISSN: 0019-5189 (Print)
Accession Number: 24195349
Diet, High-Fat/*adverse effects
Dose-Response Relationship, Drug
Pancreatitis, Chronic/chemically induced/*drug therapy
Abstract: A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1beta and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the levels of serum lipase, amylase, capase-1, myeloperoxidase, OSI and maintained the antioxidant status when compared to untreated EtOH and HFD fed rats. Among the 4 doses, 100 mg of TQ/kg body weight was found to provide optimum protective effect on pancreas against EtOH and HFD induced abnormal changes. Histological observations added more evidence for the anti-inflammatory effect of TQ.
Notes: Suguna, Periyanayagam