November 12, 2014
Ludzu, Enock K
Cairns, Bruce A
Charles, Anthony G
Int J Surg Case Rep. 2013;4(12):1130-3. doi: 10.1016/j.ijscr.2013.10.009. Epub 2013 Oct 21.
Author Address: Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: firstname.lastname@example.org.
Reference Type: Journal Article
Record Number: 4768Author: Sang, G., Du, J. M., Chen, Y. Y., Chen, Y. B., Chen, J. X. and Chen, Y. C.
Title: Plasma copeptin levels are associated with prognosis of severe acute pancreatitis
Short Title: Plasma copeptin levels are associated with prognosis of severe acute pancreatitis
Alternate Journal: Peptides
ISSN: 1873-5169 (Electronic)
Accession Number: 24184419
Multiple Organ Failure/*blood/mortality/pathology
Severity of Illness Index
Abstract: Copeptin reflects the individual stress level, and is correlated with outcomes of critical illness. This study was designed to evaluate its relationship with disease severity, local complications, organ failure and mortality of severe acute pancreatitis (SAP). Seventy-eight SAP patients and 78 sex- and age-matched healthy individuals were recruited. Plasma samples were obtained on admission from SAP patients and at study entry from healthy individuals. Copeptin concentration was determined using enzyme-linked immunosorbent assay. Plasma copeptin level was obviously higher in patients than in healthy individuals, was identified as an independent predictor of local complications, organ failure and in-hospital mortality, was highly associated with traditional predictors of disease severity and mortality including the Acute Physiology and Chronic Health Care Evaluation II score, Ranson score, multiple organ dysfunction score, sequential organ failure assessment score, and predicted local complications, organ failure, and in-hospital mortality of SAP patients with high areas under receiver operating characteristic curve. Furthermore, its predictive value was similar to the traditional predictors’. However, it could not improve these traditional predictors’ predictive values. Therefore, increased plasma copeptin level is associated with disease severity and identified as a novel prognostic marker of local complications, organ failure and mortality after SAP.