November 12, 2014
Notes: Rebibo, Lionel
Hepatobiliary Pancreat Dis Int. 2013 Dec;12(6):637-44.
Author Address: Department of Digestive Surgery, Amiens University Medical Center and the Jules Verne University of Picardie, Amiens, France. firstname.lastname@example.org.
Reference Type: Journal Article
Record Number: 4762Author: Robles, L., Vaziri, N. D. and Ichii, H.
Title: Role of Oxidative Stress in the Pathogenesis of Pancreatitis: Effect of Antioxidant Therapy
Journal: Pancreat Disord Ther
Date: Apr 1
Short Title: Role of Oxidative Stress in the Pathogenesis of Pancreatitis: Effect of Antioxidant Therapy
Alternate Journal: Pancreatic disorders & therapy
ISSN: 2165-7092 (Print)
Accession Number: 24808987
Abstract: Oxidative stress plays an important role in the pathogenesis of acute pancreatitis. The exact pathogenesis of pancreatitis remains unknown but several mechanisms related to oxidative and inflammatory stress are implicated. It is reasonable to surmise that antioxidants would play a protective role in ameliorating the deleterious effects of pancreatitis. We have a wealth of data from animal models that reveal a positive correlation between antioxidant drugs and improved outcomes in experimental pancreatitis. Human clinical trials with antioxidants however, have disclosed conflicting results. We review the existing pathogenesis of pancreatitis related to oxidative stress and provide of a review of current trials with antioxidant therapy.
Notes: Robles, Lourdes
Vaziri, Nosratola D
KL2 TR000147/TR/NCATS NIH HHS/
UL1 TR000153/TR/NCATS NIH HHS/
Pancreat Disord Ther. 2013 Apr 1;3(1):112.