November 12, 2014
Notes: Qu, Li-Mei
Brigstock, David R
5R01AA016003/AA/NIAAA NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov’t
World J Gastroenterol. 2013 Dec 28;19(48):9490-4. doi: 10.3748/wjg.v19.i48.9490.
Author Address: Li-Mei Qu, Xiao-Yu Wen, Yong-Fang Liu, Ya-Jun Li, Run-Ping Gao, Department of Hepatic-Biliary-Pancreatic Medicine, First Hospital, Jilin University, Changchun 130021, Jilin Province, China.
Reference Type: Journal Article
Record Number: 4756Author: Rajesh, G., Girish, B. N., Vaidyanathan, K. and Balakrishnan, V.
Title: Diet, nutrient deficiency and chronic pancreatitis
Journal: Trop Gastroenterol
Short Title: Diet, nutrient deficiency and chronic pancreatitis
Alternate Journal: Tropical gastroenterology : official journal of the Digestive Diseases Foundation
ISSN: 0250-636X (Print)
Accession Number: 24377152
Keywords: Dietary Fats/*administration & dosage
Dietary Proteins/*administration & dosage
Micronutrients/*administration & dosage
Pancreatitis, Chronic/complications/*diet therapy
Abstract: The aetiopathogenesis of chronic pancreatitis (CP) appears to be multifactorial with interplay of genetic and environmental factors such as alcohol, smoking and diet. Dietary factors in the form of a fat- and protein-rich diet are important cofactors in the aetiopathogenesis of alcoholic pancreatitis. Malnutrition used to be a hallmark in tropical pancreatitis. Presently, it appears that malnutrition is an effect rather than a causative factor for tropical pancreatitis; however, micronutrient deficiency could possibly be implicated in the aetiopathogenesis. The role of dietary toxins such as cassava is no longer considered an important risk factor; however, these patients are at a higher risk for defective detoxification of cyanogens. Decrease in levels of sulphur amino acids (SAAs), folate and zinc have been reported. Oxidative stress and antioxidant depletion are key pathogenetic mechanisms. The role of antioxidants in pain relief is an area of interest. Supplementation of fat-soluble vitamins and micronutrients is a cornerstone in medical management. Folate and zinc supplementation may be beneficial and is a focus of ongoing research. In the future, prophylaxis for CP by a daily micronutrient tablet among high-risk groups in endemic areas could prove to be a potentially important public health measure. However, further studies are required.