November 12, 2014
Animals, Outbred Strains
Fatty Acids, Omega-3/*administration & dosage
Fatty Acids, Unsaturated/analysis/*metabolism
Leukocytes, Mononuclear/*drug effects/metabolism/pathology
Lipid Peroxidation/drug effects
Pancreatitis, Acute Necrotizing/chemically induced/*drug
Reactive Oxygen Species/antagonists & inhibitors/metabolism
Abstract: In an experimental model of acute pancreatitis (AP) in rats no alteration in leukocyte’s viability was found by flow cytometry as compared to control. After 1 day of AP production of reactive oxygen forms in granulocytes was increased more than 5 times, but after 3 days their level was decreased. Alterations of pro/antioxidant status and specific changes in the fatty acid composition in the pancreas were established. With the development of AP, the processes of lipids peroxidation were intensified while antioxidant system was altered, that was evidenced by inflammation in the pancreas. In these conditions, the increase of phospholipase A2 activity was accompanied by significant changes of fatty acid composition of the total lipids in the pancreas. This increased relative total content of saturated fatty acids, in particular myristic, palmitic and stearic acid increased, while the total content of polyunsaturated essential fatty acids omega-3 (linolenic, eicosapentaenoic, dokozapentayenoic, docosahexaenoic) decreased. The preparation containing omega-3 polyunsaturated fatty acids partially normalized the lipid and fatty acids composition as well as prooxidant-antioxidant system.
Notes: Pryvrots’ka, I B
Kuchmerovs’ka, T M
Ukr Biokhim Zh. 2013 Sep-Oct;85(5):124-36.
Reference Type: Journal Article
Record Number: 4754Author: Qin, Y., Liao, P., He, S., Yin, Y., Song, S., Hu, J. and Zheng, P.