November 12, 2014
Notes: Monib, Sherif M
El-Barbary, Hany M
Indian J Surg. 2013 Jun;75(Suppl 1):340-4. doi: 10.1007/s12262-012-0701-7. Epub 2012 Jul 18.
Author Address: Department of Surgery, Mouwasat Hospital, Dammam, Eastern province Saudi Arabia ; Department of Surgery, Watford General Hospital, WD18 0HB Watford, Herts UK.
Department of Surgery, Mouwasat Hospital, Dammam, Eastern province Saudi Arabia.
Reference Type: Journal Article
Record Number: 4726Author: Morimoto, T., Hirai, K., Fukumura, A., Takakura, H., Koike, T. and Shimizu, T.
Title: Early diagnosis of asparaginase-associated pancreatitis based on elevated serum elastase-1 levels: Case reports
Journal: Biomed Rep
Short Title: Early diagnosis of asparaginase-associated pancreatitis based on elevated serum elastase-1 levels: Case reports
Alternate Journal: Biomedical reports
ISSN: 2049-9434 (Print)
Accession Number: 24649003
Abstract: L-asparaginase (L-asp) is a well-known anticancer agent used in the treatment of acute lymphoblastic leukemia (ALL) in children. However, it is also known to induce several acute complications, such as acute pancreatitis. This is a presentation of two pediatric acute lymphoblastic leukemia (ALL) cases of asparaginase-associated pancreatitis (AAP) diagnosed at an early stage based on elevated serum elastase-1 levels, in the presence of normal serum amylase levels. Early diagnosis and treatment of AAP, although imperative, is occasionally difficult if only standard diagnostic procedures are followed. Elastase-1 is a potentially useful marker for the early diagnosis of AAP. Therefore, the measurement of elastase-1 levels, in addition to amylase and lipase levels, is recommended in L-asp-treated patients.