November 8, 2014
Notes: Scott, Danny W
Miller, William H
Erb, Hollis N
J Feline Med Surg. 2013 Apr;15(4):307-16. doi: 10.1177/1098612X12468922. Epub 2012 Nov 27.
Author Address: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. email@example.com
Reference Type: Journal Article
Record Number: 4305Author: Serna, P. Mj
Title: Comments on: “are there moral obligations to cosmetic dermatology patients beyond informed consent?”
Journal: J Am Acad Dermatol
Short Title: Comments on: “are there moral obligations to cosmetic dermatology patients beyond informed consent?”
Alternate Journal: Journal of the American Academy of Dermatology
ISSN: 1097-6787 (Electronic)
Accession Number: 24124814
Keywords: Cosmetic Techniques/*ethics
Notes: Serna P, Maria J
J Am Acad Dermatol. 2013 Nov;69(5):817. doi: 10.1016/j.jaad.2013.04.068.
Author Address: Navaderma, Navarra, Spain. Electronic address: firstname.lastname@example.org.
Reference Type: Journal Article
Record Number: 4516Author: Serravallo, M., Jagdeo, J., Glick, S. A., Siegel, D. M. and Brody, N. I.
Title: Sirtuins in dermatology: applications for future research and therapeutics
Journal: Arch Dermatol Res
Short Title: Sirtuins in dermatology: applications for future research and therapeutics
Alternate Journal: Archives of dermatological research
ISSN: 1432-069X (Electronic)
Accession Number: 23377138
Keywords: Biomedical Research/trends
Abstract: Sirtuins are a family of seven proteins in humans (SIRT1-SIRT7) that are involved in multiple cellular processes relevant to dermatology. The role of sirtuins in other organ systems is established. However, the importance of these proteins in dermatology is less defined. Recently, sirtuins gained international attention because of their role as “longevity proteins” that may extend and enhance human life. Sirtuins function in the cell via histone deacetylase and/or adenosine diphosphate ribosyltransferase enzymatic activity that target histone and non-histone substrates, including transcription regulators, tumor suppressors, structural proteins, DNA repair proteins, cell signaling proteins, transport proteins, and enzymes. Sirtuins are involved in cellular pathways related to skin structure and function, including aging, ultraviolet-induced photoaging, inflammation, epigenetics, cancer, and a variety of cellular functions including cell cycle, DNA repair and proliferation. This review highlights sirtuin-related cellular pathways, therapeutics and pharmacological targets in atopic dermatitis, bullous dermatoses, collagen vascular disorders, psoriasis, systemic lupus erythematosus, hypertrophic and keloid scars, cutaneous infections, and non-melanoma and melanoma skin cancer. Also discussed is the role of sirtuins in the following genodermatoses: ataxia telangiectasia, Cowden’s syndrome, dyskeratosis congenita, Rubenstein-Taybi, Werner syndrome, and xeroderma pigmentosum. The pathophysiology of these inherited diseases is not well understood, and sirtuin-related processes represent potential therapeutic targets for diseases lacking suitable alternative treatments. The goal of this review is to bring attention to the dermatology community, physicians, and scientists, the importance of sirtuins in dermatology and provide a foundation and impetus for future discussion, research and pharmacologic discovery.