Dermatology 2013

Notes: Sarita, Sasidharanpillai

Muhammed, Kunnummal

Najeeba, Riyaz

Rajan, Gopalan Nair

Anza, Khader

Binitha, Manikoth Payyanadan

Aparna, Govindan

eng

England

2013/06/08 06:00

Lepr Rev. 2013 Mar;84(1):51-64.

URL: http://www.ncbi.nlm.nih.gov/pubmed/23741882

Author Address: Department of Dermatology, Government Medical College, Calicut, Kerala, India. saritasclt@gmail.com

 

 

Reference Type:  Journal Article

Record Number: 4290Author: Sarkar, R., Chugh, S. and Garg, V. K.

Year: 2013

Title: Acitretin in dermatology

Journal: Indian J Dermatol Venereol Leprol

Volume: 79

Issue: 6

Pages: 759-71

Date: Nov-Dec

Short Title: Acitretin in dermatology

Alternate Journal: Indian journal of dermatology, venereology and leprology

ISSN: 0973-3922 (Electronic)

0378-6323 (Linking)

DOI: 10.4103/0378-6323.120721

Accession Number: 24177607

Keywords: Acitretin/*administration & dosage/pharmacokinetics

Animals

Antineoplastic Agents/administration & dosage/pharmacokinetics

Cell Differentiation/drug effects/physiology

Dermatology/*methods/trends

Humans

Keratolytic Agents/*administration & dosage/pharmacokinetics

Precancerous Conditions/pathology/prevention & control

Skin Absorption/drug effects/physiology

Skin Diseases/*drug therapy/pathology

Abstract: Acitretin, a synthetic retinoid has gradually replaced etretinate in today’s dermatologic practice because of its more favorable pharmacokinetics. Acitretin over the past 20 years has proven useful in a number of difficult-to-treat hyperkeratotic and inflammatory dermatoses and nonmelanoma skin cancers. It is effective both as monotherapy and in combination with other drugs for hyperkeratotic disorders. It is considered to be an established second line treatment for psoriasis and exerts its effect mainly due to its antikeratinizing, antiinflammatory, and antiproliferative effect. Its antineoplastic properties make it a useful agent for cancer prophylaxis. Evidence-based efficacy, side-effect profile, and approach to the use of acitretin would be discussed in this review. In addition to its approved uses, the various off label uses will also be highlighted in this section. Since its use is limited by its teratogenic potential and other adverse effects, including mucocutaneous effects and hepatotoxicity, this review would summarize the contraindications and precautions to be exercised before prescribing acitretin.

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