November 8, 2014
Notes: Sarita, Sasidharanpillai
Rajan, Gopalan Nair
Binitha, Manikoth Payyanadan
Lepr Rev. 2013 Mar;84(1):51-64.
Author Address: Department of Dermatology, Government Medical College, Calicut, Kerala, India. email@example.com
Reference Type: Journal Article
Record Number: 4290Author: Sarkar, R., Chugh, S. and Garg, V. K.
Title: Acitretin in dermatology
Journal: Indian J Dermatol Venereol Leprol
Short Title: Acitretin in dermatology
Alternate Journal: Indian journal of dermatology, venereology and leprology
ISSN: 0973-3922 (Electronic)
Accession Number: 24177607
Keywords: Acitretin/*administration & dosage/pharmacokinetics
Antineoplastic Agents/administration & dosage/pharmacokinetics
Cell Differentiation/drug effects/physiology
Keratolytic Agents/*administration & dosage/pharmacokinetics
Precancerous Conditions/pathology/prevention & control
Skin Absorption/drug effects/physiology
Skin Diseases/*drug therapy/pathology
Abstract: Acitretin, a synthetic retinoid has gradually replaced etretinate in today’s dermatologic practice because of its more favorable pharmacokinetics. Acitretin over the past 20 years has proven useful in a number of difficult-to-treat hyperkeratotic and inflammatory dermatoses and nonmelanoma skin cancers. It is effective both as monotherapy and in combination with other drugs for hyperkeratotic disorders. It is considered to be an established second line treatment for psoriasis and exerts its effect mainly due to its antikeratinizing, antiinflammatory, and antiproliferative effect. Its antineoplastic properties make it a useful agent for cancer prophylaxis. Evidence-based efficacy, side-effect profile, and approach to the use of acitretin would be discussed in this review. In addition to its approved uses, the various off label uses will also be highlighted in this section. Since its use is limited by its teratogenic potential and other adverse effects, including mucocutaneous effects and hepatotoxicity, this review would summarize the contraindications and precautions to be exercised before prescribing acitretin.