November 8, 2014
Notes: Safizadeh, H
Basra, M K A
Research Support, Non-U.S. Gov’t
Qual Life Res. 2014 Apr;23(3):869-75. doi: 10.1007/s11136-013-0514-6. Epub 2013 Sep 20.
Author Address: Research Center for Social Determinants of Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Reference Type: Journal Article
Record Number: 4428Author: Saka, B., Mouhari-Toure, A., Wateba, I. M., Akakpo, S., Kombate, K., Balaka, A., Sogan, A., Afolabi, K. O., Pitche, P. and Tchangai-Walla, K.
Title: [AIDS related Kaposi sarcoma: 103 cases in dermatology in Lome (Togo)]
Journal: Med Sante Trop
Short Title: [AIDS related Kaposi sarcoma: 103 cases in dermatology in Lome (Togo)]
Alternate Journal: Medecine et sante tropicales
ISSN: 2261-2211 (Electronic)
Original Publication: Maladie de Kaposi associee au VIH : 103 observations en dermatologie a Lome (Togo).
Accession Number: 23692859
Keywords: *AIDS-Related Opportunistic Infections/drug therapy/epidemiology
*Sarcoma, Kaposi/drug therapy/epidemiology
Abstract: OBJECTIVE: The purpose of this study was to describe the epidemiological and clinical profile and the treatment and natural history of AIDS-related Kaposi sarcoma in 3 major dermatology departments in Lome (Togo). PATIENTS AND METHOD: This retrospective, descriptive study was based on the records of patients with AIDS-related Kaposi sarcoma from January 2005 through October 2011. RESULTS: During the study period, 157 patients were treated in the dermatology departments for Kaposi sarcoma. HIV serology was positive for 103 (89.6%) of the 115 patients tested. Seventy-nine patients were known to be HIV-positive before the consultation, while Kaposi sarcoma was the circumstance of discovery of the HIV infection for 24. The average age of the 103 patients was 36.7+/-14.9 years and the sex-ratio (M/F) was 1.1. The main locations of the lesions were the lower limbs (n = 76), mucosa (n = 53), trunk (n = 38) and upper limbs (n = 17). The average CD4-cell count was 226+/-168 cells/mm(3). The main antiretroviral protocol used was stavudine/lamivudine/nevirapine (70 cases). Besides the antiretroviral treatment, chemotherapy was prescribed, with vinblastine for 17 patients, bleomycin for 5, and doxorubicin for one. For financial reasons, 80 other patients did not receive chemotherapy and were lost to follow-up after an average duration of 3 months. At 5 months, the rate of complete remission was 21.1%, partial remission 21.1%, and failure 57.8%. Side effects were dominated by hematologic and nervous complications. CONCLUSION: Our study highlighted a high prevalence of AIDS-related Kaposi sarcoma in dermatology departments in Lome, with a tendency to gender equality. It also shows the difficulties of access to chemotherapy for most patients and the poor efficacy of chemotherapy.