Dermatology 2013

Notes: Narahari, Saravu R

Prasanna, Kodimoole S

Sushma, Kandathu V

eng

India

2013/05/30 06:00

Indian J Dermatol. 2013 Mar;58(2):127-31. doi: 10.4103/0019-5154.108046.

URL: http://www.ncbi.nlm.nih.gov/pubmed/23716802

Author Address: Director, Institute of Applied Dermatology, IAD Junction, Uliyathadka, Madhur Road, Kasaragod, Kerala, India.

 

 

Reference Type:  Journal Article

Record Number: 4419Author: Narayanasetty, N. K., Pai, V. V. and Athanikar, S. B.

Year: 2013

Title: Annular lesions in dermatology

Journal: Indian J Dermatol

Volume: 58

Issue: 2

Pages: 157

Date: Mar

Short Title: Annular lesions in dermatology

Alternate Journal: Indian journal of dermatology

ISSN: 1998-3611 (Electronic)

0019-5154 (Linking)

DOI: 10.4103/0019-5154.108071

PMCID: 3657228

Accession Number: 23716818

Notes: Narayanasetty, Naveen Kikkeri

Pai, Varadraj V

Athanikar, Sharatchandra B

eng

India

2013/05/30 06:00

Indian J Dermatol. 2013 Mar;58(2):157. doi: 10.4103/0019-5154.108071.

URL: http://www.ncbi.nlm.nih.gov/pubmed/23716818

Author Address: Department of Dermatology, Sri Dharmasthala Manjunatheshwara College of Medical Sciences and Hospital (SDMCMS and H), Sattur, Dharwad, India.

 

 

Reference Type:  Journal Article

Record Number: 4570Author: Nassar, D., Sbidian, E., Bastuji-Garin, S., Martin, L. and Dupuy, A.

Year: 2013

Title: Typology of the primary outcome construction in dermatology: a systematic review of published randomized controlled trials

Journal: J Invest Dermatol

Volume: 133

Issue: 2

Pages: 371-6

Date: Feb

Short Title: Typology of the primary outcome construction in dermatology: a systematic review of published randomized controlled trials

Alternate Journal: The Journal of investigative dermatology

ISSN: 1523-1747 (Electronic)

0022-202X (Linking)

DOI: 10.1038/jid.2012.279

Accession Number: 22931921

Keywords: *Dermatology

Humans

Randomized Controlled Trials as Topic/*methods

*Research Design

Skin Diseases/*therapy

Abstract: The primary outcome is a major component of a randomized clinical trial (RCT) and several types of outcome can be chosen in a given disease. We systematically reviewed RCTs on nonneoplastic dermatological diseases published in 2009 and referenced in Medline, and described how the main outcome was defined and constructed. We assessed whether those characteristics were associated with a clearly defined primary outcome and whether they were associated with a significant statistical test for the primary outcome. Outcome construction variables were the three “VIP” questions (V denoting Variable: binary vs. quantitative variable; I denoting Item: data collection based on multiple vs. single item(s); and P denoting time Points: outcome assessment based on a “final time point” vs. “final and initial time points”). Among 122 RCTs, 32% did not have a clearly defined primary outcome. In multivariable analyses, a clearly defined primary outcome was associated with a binary variable (odds ratio (OR)=6.7; 2.5-17.7) and the composite variable “both blinding/placebo-controlled arm” (OR=4.5; 1.8-11.2); a significant statistical test was associated with a “final time point”-based outcome construction (OR=2.6; 1.2-5.5). Our study points to areas of improvement related to the definition and construction of the primary outcome in RCTs in dermatology.

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