November 8, 2014
Notes: McCleskey, Patrick E
J Am Acad Dermatol. 2013 Aug;69(2):273-9. doi: 10.1016/j.jaad.2012.12.955. Epub 2013 Feb 14.
Author Address: Uniformed Services University of the Health Sciences, Bethesda, Maryland, and Department of Dermatology, David Grant Medical Center, Travis Air Force Base, California, USA. Patrick.email@example.com
Reference Type: Journal Article
Record Number: 4498Author: McIsaac, M. A., Cook, R. J. and Poulin-Costello, M.
Title: Incomplete data in randomized dermatology trials: consequences and statistical methodology
Short Title: Incomplete data in randomized dermatology trials: consequences and statistical methodology
Alternate Journal: Dermatology
ISSN: 1421-9832 (Electronic)
Accession Number: 23446106
Keywords: Data Collection/*statistics & numerical data
Dermatologic Agents/*therapeutic use
Patient Compliance/*statistics & numerical data
Randomized Controlled Trials as Topic/*standards
*Statistics as Topic
Abstract: Randomized clinical trials can provide the highest level of evidence regarding the effectiveness of therapeutic interventions. When individuals in trials do not complete the planned treatment period it is often not possible to observe the desired outcomes, which results in incomplete data. Here we review various mechanisms which can lead to incomplete data, discuss the impact of these mechanisms, and present strategies for dealing with incomplete data. We discuss these issues in the context of clinical trials in dermatology and provide practical recommendations for planning and drawing conclusions from studies which could involve incomplete data.
Notes: McIsaac, Michael A
Cook, Richard J
Dermatology. 2013;226(1):19-27. doi: 10.1159/000346247. Epub 2013 Feb 23.