Dermatology 2013

Notes: Gee, Sarah N

Zakhary, Lisa

Keuthen, Nancy

Kroshinsky, Daniela

Kimball, Alexa Boer

eng

2012/09/08 06:00

J Am Acad Dermatol. 2013 Jan;68(1):47-52. doi: 10.1016/j.jaad.2012.04.007. Epub 2012 Sep 3.

URL: http://www.ncbi.nlm.nih.gov/pubmed/22954748

Author Address: Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

 

 

Reference Type:  Journal Article

Record Number: 4393Author: Gholam, P., Kroehl, V. and Enk, A. H.

Year: 2013

Title: Dermatology life quality index and side effects after topical photodynamic therapy of actinic keratosis

Journal: Dermatology

Volume: 226

Issue: 3

Pages: 253-9

Short Title: Dermatology life quality index and side effects after topical photodynamic therapy of actinic keratosis

Alternate Journal: Dermatology

ISSN: 1421-9832 (Electronic)

1018-8665 (Linking)

DOI: 10.1159/000349992

Accession Number: 23796769

Keywords: Aged

Aged, 80 and over

Aminolevulinic Acid/*therapeutic use

Edema/etiology

Erythema/etiology

Facial Dermatoses/*drug therapy

Female

Humans

Keratosis, Actinic/*drug therapy

Male

Middle Aged

Pain/etiology

Pain Measurement

Photochemotherapy/*adverse effects

Photosensitizing Agents/*therapeutic use

Pruritus/etiology

*Quality of Life

Time Factors

Abstract: BACKGROUND: Photodynamic therapy (PDT) is an excellent treatment option for actinic keratosis. However the side effects lead to an impairment of the patients’ quality of life. OBJECTIVES: To evaluate the impact of PDT on patients’ quality of life and to determine the frequency and intensity of side effects over the course of 4 weeks post PDT. PATIENTS AND METHODS: 22 patients with actinic keratosis in the face were included into this prospective study. Pain was measured using a visual analog scale immediately and 8 h after PDT. The Dermatology Life Quality Index (DLQI) was assessed at screening, after treatment as well as 2 and 4 weeks after PDT. The physician and patient evaluated the intensity of side effects during the treatment, 2 and 4 weeks post PDT. Additionally, the patient documented side effects daily from the 1st to the 14th day after PDT and on day 28 post PDT, using a diary. RESULTS: We observed a significant (p < 0.001) increase in the DLQI from 1.6 +/- 1.7 prior to PDT to 7.3 +/- 4.9 post PDT. The DLQI normalized in the following 4 weeks. Immediately and 8 h after PDT mean pain was 4.3 +/- 2.5 and 2.3 +/- 2.1. Side effects documented by the patients were erythema (100%), pain, burning, edema (90.9%), itching (86.4%), scaling (81.8%) and pustules (59.1%). No scar formation, hyper-/hypopigmentation or infections were observed. CONCLUSION: PDT has a significant temporary impact on patients’ DLQI. Transitory side effects are common and show typical kinetics.

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