Dermatology 2013

Notes: Dixit, Shreya

Lowe, Patricia

Fischer, Gayle

Lim, Adrian

eng

Australia

2013/04/27 06:00

Australas J Dermatol. 2013 Nov;54(4):273-6. doi: 10.1111/ajd.12057. Epub 2013 Apr 26.

URL: http://www.ncbi.nlm.nih.gov/pubmed/23617804

Author Address: Department of Dermatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

 

 

Reference Type:  Journal Article

Record Number: 4349Author: Dosekun, O., Farrugia, P., Lewis, F. and Sethi, G.

Year: 2013

Title: Vulval disease in HIV-positive women attending a tertiary vulval dermatology clinic over a five-year period

Journal: Int J STD AIDS

Volume: 24

Issue: 10

Pages: 834-6

Date: Oct

Short Title: Vulval disease in HIV-positive women attending a tertiary vulval dermatology clinic over a five-year period

Alternate Journal: International journal of STD & AIDS

ISSN: 1758-1052 (Electronic)

0956-4624 (Linking)

DOI: 10.1177/0956462413486458

Accession Number: 23970605

Keywords: Adult

Aminoquinolines/therapeutic use

Antineoplastic Agents/therapeutic use

CD4 Lymphocyte Count

Carcinoma, Squamous Cell/etiology/therapy

Cervical Intraepithelial Neoplasia/*diagnosis/drug therapy/pathology

Female

HIV Infections/*complications/drug therapy/virology

Humans

Middle Aged

Treatment Outcome

Uterine Cervical Neoplasms/*diagnosis/drug therapy/pathology

Vulvar Diseases/drug therapy/*etiology/microbiology

Abstract: There is a paucity of data on vulval disease in HIV-infected women. We describe the spectrum of vulval disease in HIV-infected women attending a tertiary vulval dermatology referral centre over a five-year period. Seven vulval conditions were identified in 14 women. Most were attending for HIV care (n = 12, 86%), and on combined antiretroviral therapy (CART) with a CD4 cell count above 200 cells/microL (n = 9, 64%) at diagnosis. Imiquimod therapy was effective in treating undifferentiated vulval intraepithelial neoplasia (uVIN) – the most common diagnosis. There were no cases of invasive vulval carcinoma. Hypertrophic herpes simplex virus occurred in one woman stable on CART with good immune reconstitution. Clinicians should be vigilant about the spectrum of vulval disease in HIV-infected women and consider genital examination as part of routine care.

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